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Provedor de dados:  Rev. Bras. Ciênc. Avic.
País:  Brazil
Título:  Oxidative Stress of in-Ovo Ochratoxin A Administered during Chick Embryonic Development
Autores:  Elsayed,MAE
Data:  2019-01-01
Ano:  2019
Palavras-chave:  Chicken Embryo
Ochratoxin A
Oxidative Stress
Liver and Kidney Functions
Total Thyroxine
Resumo:  ABSTRACT The present work was carried out to study the effect of in-ovo injection of ochratoxin A (OTA) as an oxidative stress and its consequences on hepatic and kidney functions, thyroid activity, and histological examination of brain and liver in chicken embryos and subsequently in the hatching chicks. On the 10th day of incubation, one hundred and sixty-two fertile eggs were randomly divided into two equal treatments. Control treatment, (injected by 50 µl sodium carbonate) and OTA treatment (injected by 12.5 ng OTA dissolved in 50 µl sodium carbonate). OTA treatement group significantly reduced glutathione (GSH) and significantly increased thiobarbituric acid reactive substances production (TBARS) in embryonic and hatched chicks regarding livers, spleen, bursa of Fabricius, heart, and brain as an indicator of oxidative stress. OTA injection increased TBARS and decreased GSH levels in both allantoic and amniotic fluids. On the 14th and 16th days of incubation and at the hatch, a significant lower concentration in cholesterol and higher concentrations of alanine amino transferase, aspartate amino transferase, alkaline phosphatase, gamma glutamyl transferase, acid phosphatase enzymes activities and triglycerides in the hepatic tissues of the OTA group were observed. Histological examination of OTA group of brain and liver tissues showed some degenerative changes through the experimental period. In conclusion, in-ovo OTA treated had teratogenic and embryotoxic effects.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Fundação APINCO de Ciência e Tecnologia Avícolas
Relação:  10.1590/1806-9061-2017-0637
Formato:  text/html
Fonte:  Brazilian Journal of Poultry Science v.21 n.1 2019
Direitos:  info:eu-repo/semantics/openAccess

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