Consulta: creatorFacets:"ANDRADE,VANESSA M. DE"
Registros recuperados: 4
Data/hora: 06/06/2024 05:16:47

Production, characterization and toxicology assay of creatine pegylated nanoliposome with polysorbate 80 for brain delivery
Provedor de dados: 42
Autores: BORIN,DIEGO B.; MEZZOMO,NATHANA J.; VAUCHER,RODRIGO A.; CARMO,GUILHERME DO; RODRIGUES JUNIOR,LUIZ C.; SULCZEWSKI,FERNANDO B.; SCHWERTZ,CLAITON I.; MENDES,RICARDO E.; DAMIANI,ADRIANI P.; ANDRADE,VANESSA M. DE; RECH,VIRGÍNIA C.; BOECK,CARINA R.
ABSTRACT Creatine acts intracellularly as energy buffer and storage, demonstrating protective effects in animal models of neurodegenerative diseases. However, its permeability throught blood-brain barrier (BBB) is reduced. The aim of the present study was developing a carrier to facilitate the delivery of creatine to the central nervous system. Creatine nanoliposomes were produced, characterized and assayed in models of toxicity in vitro and in vivo. Particles showed negative zeta potential (-12,5 mV), polydispersity index 0.237 and medium-size of 105 nm, which was confirmed by transmission electron microscopy (TEM) images. Toxicity assay in vitro was evaluated with blank liposomes (no drug) or creatine nanoliposomes at concentrations of 0.02 and 0.2...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nanocarrier; Neurodegenerative diseases; Nanotechnology; Liposomes.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502317

Elemental composition of vegetables cultivated over coal-mining waste
Provedor de dados: 42
Autores: ZOCCHE,JAIRO J.; ROHR,PAULA; DAMIANI,ADRIANI P.; LEFFA,DANIELA D.; MARTINS,MIRIAM C.; ZOCCHE,CAROLINE M.; TEIXEIRA,KARINA O.; BORGES,GABRIELA D.; JESUS,MAIELLEN M. DE; SANTOS,CARLA E.I. DOS; DIAS,JOHNNY F.; ANDRADE,VANESSA M. DE.
ABSTRACT We assessed elemental composition of the liver in mice subjected to one-time or chronic consumption of the juice of vegetables cultivated in a vegetable garden built over deposits of coal waste. Lactuca sativa L. (lettuce), Beta vulgaris L. (beet), Brassica oleracea L. var. italica (broccoli) and Brassica oleracea L. var. acephala (kale) were collected from the coal-mining area and from a certified organic farm (control). Elemental composition was analyzed by particle-induced X-ray emission (PIXE) method. Concentrations of Mg, S, and Ca of mice subjected to one-time consumption of broccoli and concentrations of these same elements plus Si of mice receiving kale were higher in the coal-mining area. Concentrations of P, K, and Cu were increase after...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coal; Anthropogenic soil; Trace elements; Heavy metals; Plants; PIXE.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502383

Evaluation of the mutagenic effect of the iodinated contrast medium Urografina® 292 using the micronucleus test in mouse bone marrow cells
Provedor de dados: 42
Autores: BELLE,MONICA B.B.; LEFFA,DANIELA D.; MAZZORANA,DALIANE; ANDRADE,VANESSA M. DE.
Contrast media (CM) are frequently used in diagnostic radiology and in radiotherapy as a diagnostic tool and in treatment planning. Previous studies have demonstrated that these compounds induce chromosomal aberrations. This study evaluates the mutagenic effects induced by the contrast medium Urografina® 292 (meglumine amidotrizoate and sodium-ionic dimmer) in bone marrow cells (BMC) of mice in vivo. Micronuclei assay was performed in BMC of CF-1 mice injected with CM 1.5 and 3.0 mL/kg intravenous doses and 1.0, 2.0, 3.0 mL/kg intraperitoneal doses. The animals were beheaded 24 h after treatment by cervical dislocation, and femur BMC from each animal were used in the micronucleus test. The group treated with the highest intravenous injection of Urografina®...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chromosomes; Contrast medium; Micronuclei; Urografina® 292.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000200737

Hibiscus acetosella extract protects against alkylating agent-induced DNA damage in mice
Provedor de dados: 42
Autores: VILELA,THAIS C.; LEFFA,DANIELA D.; DAMIANI,ADRIANI P.; DAMAZIO,DAIANE DAL COL; MANENTI,ALINE V.; CARVALHO,TIAGO JOSÉ G.; RAMLOV,FERNANDA; AMARAL,PATRICIA A.; ANDRADE,VANESSA M. DE.
Abstract Hibiscus acetosella was shown to exert beneficial effects in humans and animal models however, the effects of this plant on DNA are unknown. The aim of this study was to determine the antigenotoxic and antimutagenic effects of H. acetosella extracts on alkylating agent methyl methanesulfonate (MMS) in vivo in mice. Initially, we performed analysis of phenolic compounds in extracts of H. acetosella by high-performance liquid chromatography (HPLC). Next, mice were divided into 8 groups and treated with distilled water or plant extract (0.1 ml/10 g) by gavage for 15 days, followed by intraperitoneal (ip) administration of saline solution or MMS (40 mg/Kg b.w) on day 16. Caffeic acid, following by gallic acid, gallocatechin, coumaric acid, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hibiscus acetosella; Antigenotoxicity; Comet assay; Antimutagenicity; Micronucleus test.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000603165