Consulta: creatorFacets:"Achkar,S. M."
Registros recuperados: 1
Data/hora: 08/06/2024 05:33:07

Immunopathology of rabies infection in mice selected for high or low acute inflammatory reaction
Provedor de dados: 80
Autores: Achkar,S. M.; Sinhorini,I. L.; Ribeiro,O. G.; Carrieri,M. L.; Ceretta,R. S.; Consales,C. A.
Rabies is a severe and lethal disease that produces a slight inflammatory response during the infection process. We analyzed the immunopathological mechanisms that occur in the central nervous system (CNS) using mice genetically selected for maximal or minimal acute inflammatory reaction (AIRmax or AIRmin). As viral samples, we adopted the antigenic variant 3 (AgV3) of rabies virus from hematophagous bats and a fixed virus strain (PV1 43/3). Titration of specific antibodies was performed using enzyme-linked immunosorbent assay (ELISA). We observed a slight increase in IgG and IgG1 isotypes in infected AIRmax mice. Incubation period, determined by intracerebral inoculation with 100 LD50, was 6-7 days for PV1 43/4 strain and 9-10 days for AgV3. No difference...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rabies; Virus replication; Pathology; Inflammation; Immunoglobulin isotypes.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000100003