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Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
Provedor de dados: 64
Autores: Paiva,Rojane de Oliveira; Kneipp,Lucimar Ferreira; Goular,Carla Marins; Albuquerque,Mariana Almeida; Echevarria,Aurea.
Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A. ochraceus, A. parasiticus and Fusarium verticillioides. Thiosemicarbazones had MIC values of 125-500 µg/ml. The thiosemicarbazones 1 and 2 exerted fungistatic activity against Aspergillus spp., and thiosemicarbazone 2 exerted fungicidal activity against F. verticillioides. Compound 2 showed an iron chelating effect of 63%. The ergosterol content of A. parasiticus had a decrease of 28 and 71% for the 31.2 and 62.5 µg/ml concentrations of thiosemicarbazone 2 compared to the control. The obtained results of antifungal...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aspergillus; Fusarium; Mycotoxicology; Thiosemicarbazones.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542014000600001