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Alcohol dependence induced in rats by semivoluntary intermittent intake
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Macieira,M.S.; Almeida,W.G.; Silva,E.A.; Schenberg,L.C.; Nakamura-Palacios,E.M.
The objective of the present experiment was to assess ethyl alcohol (ETOH) dependence brought about by a semivoluntary intermittent intake regimen in rats. Male Wistar rats weighing 150-250 g at the onset of the experiment were assigned to the following groups: 0% ETOH (N = 11), 5% ETOH (N = 20), 20% ETOH (N = 20) and 40% ETOH (N = 18). ETOH solutions were offered at the end of the day and overnight from Monday to Friday, and throughout weekends, for 90 days. The concentration of the ETOH solutions was increased in a stepwise fashion allowing the rats to get used to the taste of alcohol. Reposition of pure water was permitted during 1-h water drinking periods in the morning. Daily volume intake (± SEM) averaged 25.4 ± 0.4 ml (0% ETOH), 23.8 ± 0.6 ml (5%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ethanol; Alcohol; Drug dependence; Rat.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000900009