Consulta: creatorFacets:"Alves-Do-Prado,Wilson"
Registros recuperados: 2
Data/hora: 10/06/2024 13:40:58

Antagonism by hemoglobin of effects induced by L-arginine in neuromuscular preparations from rats
Provedor de dados: 56
Autores: Ambiel,C.R.; Alves-Do-Prado,Wilson.
Nitric oxide (NO)-synthase is present in diaphragm, phrenic nerve and vascular smooth muscle. It has been shown that the NO precursor L-arginine (L-Arg) at the presynaptic level increases the amplitude of muscular contraction (AMC) and induces tetanic fade when the muscle is indirectly stimulated at low and high frequencies, respectively. However, the precursor in muscle reduces AMC and maximal tetanic fade when the preparations are stimulated directly. In the present study the importance of NO synthesized in different tissues for the L-Arg-induced neuromuscular effects was investigated. Hemoglobin (50 nM) did not produce any neuromuscular effect, but antagonized the increase in AMC and tetanic fade induced by L-Arg (9.4 mM) in rat phrenic nerve-diaphragm...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Skeletal muscle; Nitric oxide; Tetanic fade; L-arginine; D-arginine; Hemoglobin.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400017

Effects of L-arginine on the diaphragm muscle twitches elicited at different frequencies of nerve stimulation
Provedor de dados: 56
Autores: Queiroz,R.N.; Alves-Do-Prado,Wilson.
In rats, the nitric oxide (NO)-synthase pathway is present in skeletal muscle, vascular smooth muscle, and motor nerve terminals. Effects of NO were previously studied in rat neuromuscular preparations receiving low (0.2 Hz) or high (200 Hz) frequencies of stimulation. The latter frequency has always induced tetanic fade. However, in these previous studies we did not determine whether NO facilitates or impairs the neuromuscular transmission in preparations indirectly stimulated at frequencies which facilitate neuromuscular transmission. Thus, the present study was carried out to examine the effects of NO in rat neuromuscular preparations indirectly stimulated at 5 and 50 Hz. The amplitude of muscular contraction observed at the end (B) of a 10-s...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Skeletal muscle; Nitric oxide; L-arginine; Neuromuscular transmission; Tetanic fade; S-nitroso-N-acetylpenicillamine; Superoxide dismutase.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600020