Consulta: creatorFacets:"Ambiel,C.R."
Registros recuperados: 2
Data/hora: 10/06/2024 08:48:37

Antagonism by hemoglobin of effects induced by L-arginine in neuromuscular preparations from rats
Provedor de dados: 56
Autores: Ambiel,C.R.; Alves-Do-Prado,Wilson.
Nitric oxide (NO)-synthase is present in diaphragm, phrenic nerve and vascular smooth muscle. It has been shown that the NO precursor L-arginine (L-Arg) at the presynaptic level increases the amplitude of muscular contraction (AMC) and induces tetanic fade when the muscle is indirectly stimulated at low and high frequencies, respectively. However, the precursor in muscle reduces AMC and maximal tetanic fade when the preparations are stimulated directly. In the present study the importance of NO synthesized in different tissues for the L-Arg-induced neuromuscular effects was investigated. Hemoglobin (50 nM) did not produce any neuromuscular effect, but antagonized the increase in AMC and tetanic fade induced by L-Arg (9.4 mM) in rat phrenic nerve-diaphragm...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Skeletal muscle; Nitric oxide; Tetanic fade; L-arginine; D-arginine; Hemoglobin.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400017

Reversal by methylene blue of tetanic fade induced in cats by nitric oxide
Provedor de dados: 56
Autores: Ambiel,C.R.; Alves-Do-Prado,W.
Previous data from our laboratory have indicated that nitric oxide (NO) acting at the presynaptic level increases the amplitude of muscular contraction (AMC) of the phrenic-diaphragm preparations isolated from indirectly stimulated rats, but, by acting at the postsynaptic level, it reduces the AMC when the preparations are directly stimulated. In the present study we investigated the effects induced by NO when tetanic frequencies of stimulation were applied to in vivo preparations (sciatic nerve-anterior tibial muscle of the cat). Intra-arterial injection of NO (0.75-1.5 mg/kg) induced a dose-dependent increase in the Wedensky inhibition produced by high frequencies of stimulation applied to the motor nerve. Intra-arterial administration of 7.2 µg/kg...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Wedensky inhibition; Nitric oxide; Methylene blue; Skeletal muscle.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000300013