Consulta: creatorFacets:"Antunes,João Marcelo Azevedo de Paula"
Registros recuperados: 3
Data/hora: 10/06/2024 16:11:18

Evaluation of short-interfering RNAs treatment in experimental rabies due to wild-type virus
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Appolinario,Camila Michele; Allendorf,Susan Dora; Peres,Marina Gea; Fonseca,Clovis Reynaldo; Vicente,Acacia Ferreira; Antunes,João Marcelo Azevedo de Paula; Pantoja,José Carlos Figueiredo; Megid,Jane.
ABSTRACTWe have evaluated the efficacy of short-interfering RNAs targeting the nucleoprotein gene and also the brain immune response in treated and non-treated infected mice. Mice were inoculated with wild-type virus, classified as dog (hv2) or vampire bat (hv3) variants and both groups were treated or leaved as controls. No difference was observed in the lethality rate between treated and non-treated groups, although clinical evaluation of hv2 infected mice showed differences in the severity of clinical disease (p = 0.0006). Evaluation of brain immune response 5 days post-inoculation in treated hv2 group showed no difference among the analyzed genes, whereas after 10 days post-inoculation there was increased expression of 2',5'-oligoadenylate synthetase...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rabies; Dog virus; Bat virus; SiRNA.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500453

Rapid serum agglutination and agar gel immunodiffusion tests associated to clinical signs in rams experimentally infected with Brucella ovis
Provedor de dados: Ciência Rural
Autores: Nozaki,Cristiane Nakada; Lira,Nair Silva Cavalcanti de; Augusto Filho,Otávio; Azevedo,Hymerson Costa; Rodello,Leandro; Dasso,Maurício Gaudério; Bicudo,Sony Dimas; Antunes,João Marcelo Azevedo de Paula; Megid,Jane.
The purpose of this study was to evaluate the agar gel immunodiffusion and the rapid serum agglutination tests associated to clinical signs in rams experimentally infected with Brucella ovis. The serological profile during the 12 months of infection showed a large fluctuation of antibodies that favors the failure in the diagnostic. The evaluation of tests after the experimental infection allowed to suggest that none of the tests were able to detect the infection throughout the period of study. The study reinforces the importance of considering the clinical signs to support the diagnosis of Brucella ovis infection in rams.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ovine infectious epididimitis; Sheep brucellosis; Diagnostic.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782011000800023

Ticks infesting wild small rodents in three areas of the state of São Paulo, Brazil
Provedor de dados: Ciência Rural
Autores: Martins,Thiago Fernandes; Peres,Marina Gea; Costa,Francisco Borges; Bacchiega,Thais Silva; Appolinario,Camila Michele; Antunes,João Marcelo Azevedo de Paula; Vicente,Acácia Ferreir; Megid,Jane; Labruna,Marcelo Bahia.
ABSTRACT: From May to September 2011, a total of 138 wild rodents of the Cricetidae family were collected in the cities of Anhembi, Bofete and Torre de Pedra, in São Paulo State. All animals were examined for the presence of ticks, which were collected and identified at species level in the laboratory by morphological examination (for adults, nymphs and larvae) and molecular biology, by sequencing of a fragment of the 16S mitochondrial rDNA (for larvae). A total of 47 ticks (21 larvae and 26 nymphs) were collected from rodents, identified as 21 larvae and 23 nymphs of Amblyomma ovale (collected on Oligoryzomys nigripes , Oligoryzomys flavescens ,  Sooretamys agouya and Nectomys squamipes ), two nymphs of Ixodes schulzei (O. nigripes and O. flavescens ) and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ticks; Wild rodents; Amblyomma ovale; Amblyomma sculptum; Ixodes schulzei; Brazil.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000500871