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Effect of LPS on the Viability and Proliferation of Human Oral and Esophageal Cancer Cell Lines
Provedor de dados: Brazilian Archives of Biology and Technology
Autores: Gonçalves,Márcia; Cappellari,Ángelica Regina; Santos Junior,André Avelino dos; Marchi,Fernanda Olicheski de; Macchi,Fernanda Souza; Antunes,Krist Helen; Souza,Ana Paula Duarte de; Morrone,Fernanda Bueno.
The esophagus and mouth tumors are very frequent malignancies worldwide. Lipopolysaccharides (LPS) are capable of regulating gene expression of pro-inflammatory cytokines by binding to toll-like receptor 4 (TLR4). Recent studies show that LPS can increase the migration ability of human esophageal cancer cell line HKESC-2 by increasing its adhesion properties. However, the effect of LPS has not been tested on viability of human esophageal and oral cancer cells. This study aimed to determine the action of LPS on the cell proliferation and viability in OE19 (adenocarcinoma) and OE21 (squamous carcinoma) cell lines, representative of human esophageal cancer, and HN30 cell line, representative of human oral carcinoma. LPS was used as treatment to OE19 and OE21...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: LPS; Oral cancer; Esophageal cancer; TLR4.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100306