Consulta: creatorFacets:"Arantes-Costa,F.M."
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Effect of salbutamol on pulmonary responsiveness in chronic pulmonary allergic inflammation in guinea pigs
Provedor de dados: 56
Autores: Kasahara,D.I.; Perini,A.; Lopes,F.D.T.Q.S.; Arantes-Costa,F.M.; Martins,M.A.; Nunes,M.P.T.
Beta-2-agonists have been widely used by asthmatic subjects to relieve their obstructive symptoms. However, there are reports that continuous use could lead to loss of bronchial protection and exacerbation of asthma symptoms. We evaluated the effect of two regimens of salbutamol administration (twice and five times a week) in a model of chronic airway inflammation in male Hartley guinea pigs (protocol starting weight: 286 ± 30 g) induced by repeated exposures to aerosols of ovalbumin (OVA). After sensitization, guinea pigs were exposed to aerosols of 0.1 mg/ml salbutamol solution twice a week (OVA + S2x, N = 7) or five times a week (OVA + S5x, N = 8). We studied allergen-specific (OVA inhalation time) and -nonspecific (response to methacholine) respiratory...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Salbutamol; Methacholine; Experimental asthma; Beta-agonist; Pulmonary responsiveness.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500009