Consulta: creatorFacets:"Ayres,Lorena Rocha"
Registros recuperados: 5
Data/hora: 04/06/2024 15:30:51

Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways
Provedor de dados: 80
Autores: Ayres,Lorena Rocha; Récio,Alex dos Reis; Burin,Sandra Mara; Pereira,Juliana Campos; Martins,Andrea Casella; Sampaio,Suely Vilela; Castro,Fabíola Attié de; Pereira-Crott,Luciana Simon.
Background Activation of the complement system plays an important role in the regulation of immune and inflammatory reactions, and contributes to inflammatory responses triggered by envenomation provoked byBothrops snakes. The present study aimed to assess whether Bothrops jararacussuand Bothrops pirajai crude venoms and their isolated toxins, namely serine protease (BjussuSP-I) and L-amino acid oxidase (BpirLAAO-I), modulate human complement system pathways.Methods Lyophilized venom and toxin samples solubilized in phosphate buffered saline were diluted in appropriate buffers to evaluate their hemolytic activity on the alternative and classical pathways of the complement system. Venom- and toxin-treated normal human serum was added to the erythrocyte...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bothrops jararacussu; Bothrops pirajai; Chemotaxis; Complement system; Kinetic microassay; L-amino acid oxidase; Serine protease; Snake venom.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100336

Adherence and/or discontinuation of imatinib mesylate in patients with chronic myeloid leukemia
Provedor de dados: 60
Autores: Alves,Alexandra Rodrigues; Lima,William Gustavo; Nagai,Michelly Martins; Rodrigues,João Paulo Vilela; Ayres,Lorena Rocha.
ABSTRACT Adherence to imatinib mesylate improves clinical outcomes and promotes a reduction in health expenditure. However, treatment duration and lack of efficacy decrease adherence to pharmacotherapy, resulting in increased mortality associated with Chronic Myeloid Leukemia. This study aimed to evaluate and compare adherence and/or discontinuation of imatinib mesylate in different studies from the literature. An integrative review of original articles published between the years of 2004 and 2014 was performed using the databases PubMed/MEDLINE, Scopus and SciELO. The descriptor "imatinib" was used in two combinations employing the connector AND between terms: "medication adherence'' AND ''imatinib" AND "leukemia'' and ''patient compliance'' AND...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic Myeloid Leukemia/treatment; Imatinib Mesylate/treatment adherence; Medication adherence; Pharmacotheraphy review.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400581

Pharmacoepidemiological profile and polypharmacy indicators in elderly outpatients
Provedor de dados: 60
Autores: Baldoni,André de Oliveira; Ayres,Lorena Rocha; Martinez,Edson Zangiacomi; Dewulf,Nathalie de Lourdes Sousa; Santos,Vânia dos; Obreli-Neto,Paulo Roque; Pereira,Leonardo Régis Leira.
This cross-sectional study was carried out with 1000 elderly outpatients assisted by a Basic Health District Unit (UBDS) from the Brazilian Public Health System (SUS) in the municipality of Ribeirão Preto. We analyzed the clinical, socioeconomic and pharmacoepidemiological profile of the elderly patients in order to identify factors associated with polypharmacy amongst this population. We used a truncated negative binomial model to examine the association of polypharmacy with the independent variables of the study. The software SAS was used for the statistical analysis and the significance level adopted was 0.05. The most prevalent drugs were those for the cardiovascular system (83.4%). There was a mean use of seven drugs per patient and 47.9% of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pharmacoepidemiology; Elderly/use of drugs; Polypharmacy; Drugs/rational use; Public Health System.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300006

Cost-effectiveness of insulin analogs from the perspective of the Brazilian public health system
Provedor de dados: 60
Autores: Cazarim,Maurílio de Souza; Rodrigues,João Paulo Vilela; Cruz-Cazarim,Estael Luzia Coelho da; Ayres,Lorena Rocha; Pereira,Leonardo Régis Leira.
ABSTRACT Human insulin is provided by the Brazilian Public Health System (BPHS) for the treatment of diabetes, however, legal proceedings to acquire insulin analogs have burdened the BPHS health system. The aim of this study was to perform a cost-effectiveness analysis to compare insulin analogs and human insulins. This is a pharmacoeconomic study of cost-effectiveness. The direct medical cost related to insulin extracted from the Ministry of Health drug price list was considered. The clinical results, i.e. reduction in glycated hemoglobin (HbA1c), were extracted by meta-analysis. Different scenarios were structured to measure the uncertainties regarding the costs and reduction in HbA1c. Decision tree was developed for sensitivity of Incremental Cost...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diabetes Mellitus/treatment/cost-effectiveness/evaluation; Prolonged Action Insulin; Short Action Insulin; Brazilian Public Health System.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300616

Pharmacists in dispensing drugs (PharmDisp): protocol for a clinical trial to test the effectiveness of distance education in training pharmacists for dispensing drugs
Provedor de dados: 60
Autores: Reis,Tiago Marques dos; Guidoni,Camilo Molino; Baldoni,André Oliveira; Giroto,Edmarlon; Obreli Neto,Paulo Roque; Ayres,Lorena Rocha; Pereira,Leonardo Régis Leira.
ABSTRACT Dispensing drug is a moment in which the pharmacist is able to analyze pharmacotherapy and contribute to its rational use. However, research has shown that some pharmacists lack adequate knowledge to perform this service. This study aims to describe a research protocol for a clinical trial to test the effectiveness of a distance learning program to train pharmacists in dispensing drugs. This is a protocol for an open diagnostic, non-randomized, single group clinical trial. A 12-week duration distance learning course was structured on the Moodle platform for training community pharmacists who are registered in the Regional Board of Pharmacy and work as employees or owners in Brazilian community pharmacies. The course curricula involves concepts and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pharmacists/distant education; Pharmacists/dispensing of drugs; Pharmacists/continuing-education.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100605