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Agaricus subrufescens: substratum nitrogen concentration and mycelial extraction method on antitumor activity
Provedor de dados: 42
Autores: BERTÉLI,MÍRIA B.D.; LOPES,ANA D.; COLLA,ITARUÃ M.; LINDE,GIANI A.; COLAUTO,NELSON B.
ABSTRACT Antitumor activity of Agaricus subrufescens has been shown on vegetative mycelium and basidiocarp. However, few studies have assessed the effect of A. subrufescens cultivation conditions and extraction methods on antitumor activity. This study evaluated the effect of nitrogen concentration on the cultivation medium of A. subrufescens and the extraction method of mycelial antineoplastic actives against sarcoma 180 cells implanted in mice. Two nitrogen sources (isolated soybean protein and NaNO3) and 10 nitrogen concentrations (0.25 to 8.0 g/L) were used. Dried mycelium extract was obtained by hot water infusion (1:10 mass:volume; 90 °C) or by aqueous mixture (1:10 mass:volume, ambient temperature) in ultrapure water. The doses were administered...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Agaricus blazei; Agaricus brasiliensis; Antineoplastic; Basidiocarp; Medicinal mushrooms; Mycelium.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602239