Consulta: creatorFacets:"Belcavello,L."
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Protective effect of the APOE-e3 allele in Alzheimer’s disease
Provedor de dados: 56
Autores: de-Almada,B.V.P.; de-Almeida,L.D.; Camporez,D.; de-Moraes,M.V.D.; Morelato,R.L.; Perrone,A.M.S.; Belcavello,L.; Louro,I.D.; de-Paula,F.
Although several alleles of susceptibility to Alzheimer’s disease (AD) have been studied in the last decades, few polymorphisms have been considered as risk factors for the disease. Among them, the APOE-e4 allele appears to be the major genetic risk factor for the onset of the disease. However, it is important to confirm the potential susceptibility of these genetic variants in different populations in order to establish a genetic profile for the disease in specific communities. This study analyzed the APOE polymorphisms regarding susceptibility to AD in a sample of 264 individuals (primarily Caucasians; 82 cases and 182 controls) in the population from Vitória, ES, Brazil, by PCR restriction fragment length polymorphism (PCR-RFLP) methods. The patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alzheimer’s disease; APOE-e3 allele; APOE-e4 allele; Brazilian population; Case-control study.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100002