Consulta: creatorFacets:"Binda,Nancy Scardua"
Registros recuperados: 1
Data/hora: 13/06/2024 13:13:38

ω-conotoxin MVIIA intralesional injection in spinal cord injury in rats
Provedor de dados: 65
Autores: Oliveira,Karen Maciel de; Binda,Nancy Scardua; Lavor,Mário Sérgio Lima; Silva,Carla Maria Osório; Rosado,Isabel Rodrigues; Taguchi,Tatiana Malagoli; Alves,Endrigo Gabellini Leonel; Melo,Marília Martins; Gomez,Marcus Vinícius; Melo,Eliane Gonçalves de.
This study aimed to investigate the neuroprotective effect of ω-conotoxin MVIIA (MVIIA) intralesional application in rats submitted to spinal cord injury. Male Wistar rats, weighing 300g±23.4, were distributed in five groups: negative control (SHAM), placebo (PLA), 5μM MVIIA, 10μM MVIIA and 20μM MVIIA MVIIA. After laminectomy of the 12th thoracic vertebra (SHAM), the PLA, 5μM MVIIA, 10μM MVIIA and 20μM MVIIA groups were subjected to acute compressive spinal cord trauma for five minutes, and then five minutes later, the animals received specific treatment in a standard total volume of 2µL, by intralesional route, using sterile PBS as placebo. Locomotor activity was assayed using Basso Beattie Bresnahan (BBB) scale to show the patterning of SCI. With 48...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MVIIA; Cone snail; Cell viability; Glutamate; Reactive oxygen species; Lipid peroxidation.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100150