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A Grow-and-Lock Model for the Control of Flagellum Length in Trypanosomes
Provedor de dados: 5
Autores: Bertiaux, Eloise; Morga, Benjamin; Blisnick, Thierry; Rotureau, Brice; Bastin, Philippe.
Several models have been proposed to explain how eukaryotic cells control the length of their cilia and flagella. Here, we investigated this process in the protist Trypanosoma brucei, an excellent model system for cells with stable cilia like photoreceptors or spermatozoa. We show that the total amount of intraflagellar transport material (IFT, the machinery responsible for flagellum construction) increases during flagellum elongation, consistent with constant delivery of precursors and the previously reported linear growth. Reducing the IFT frequency by RNAi knockdown of the IFT kinesin motors slows down the elongation rate and results in the assembly of shorter flagella. These keep on elongating after cell division but fail to reach the normal length....
Tipo: Text
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00473/58452/61033.pdf