Consulta: creatorFacets:"Brito,Alba Regina Monteiro Souza"
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Antiulcerogenic activity of Indigofera truxillensis Kunth
Provedor de dados: 49
Autores: Cola-Miranda,Maira; Barbastefano,Victor; Hiruma-Lima,Clélia Akiko; Calvo,Tamara Regina; Vilegas,Wagner; Brito,Alba Regina Monteiro Souza.
The genus Indigofera (Fabaceae) is used in folk medicine to treat gastrointestinal pain. In this study, we investigated the antiulcerogenic properties of Indigofera truxillensis Kunth. Oral administration of MeOH extract did not produce any signals of acute toxicity. The antiulcerogenic activity was assessed in different models of acute gastric ulcers (100% ethanol, piroxicam 30 mg.kg-1, hypothermic restraint stress and pylorus ligature) in mice and rats. The animals were treated with the drugs lanzoprazole (30 mg.kg-1) or cimetidine (100 mg.kg-1) as positive controls depending on the performed model. In another experiment with ethanol-induced ulcers in rats, N-ethylmaleimide (NEM), a sulfhydryl group blocker, was also used. The MeOH extract, at doses of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiulcerogenic activity; Fabaceae; Indigofera truxillensis Kunth; Medicinal plant; Phenolic compounds.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032006000300004