Consulta: creatorFacets:"Brum,P.C."
Registros recuperados: 9
Data/hora: 16/06/2024 03:40:31

Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats
Provedor de dados: 56
Autores: Medeiros,A.; Oliveira,E.M.; Gianolla,R.; Casarini,D.E.; Negrão,C.E.; Brum,P.C.
The effect of swimming training (ST) on vagal and sympathetic cardiac effects was investigated in sedentary (S, N = 12) and trained (T, N = 12) male Wistar rats (200-220 g). ST consisted of 60-min swimming sessions 5 days/week for 8 weeks, with a 5% body weight load attached to the tail. The effect of the autonomic nervous system in generating training-induced resting bradycardia (RB) was examined indirectly after cardiac muscarinic and adrenergic receptor blockade. Cardiac hypertrophy was evaluated by cardiac weight and myocyte morphometry. Plasma catecholamine concentrations and citrate synthase activity in soleus muscle were also determined in both groups. Resting heart rate was significantly reduced in T rats (355 ± 16 vs 330 ± 20 bpm). RB was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Swimming-training exercise; Cardiac autonomic balance; Hemodynamics; Hypertrophic effect; Parasympathetic system; Resting bradycardia.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001200018

Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure
Provedor de dados: 56
Autores: Medeiro,A.; Vanzelli,A.S.; Rosa,K.T.; Irigoyen,M.C.; Brum,P.C.
The present investigation was undertaken to study the effect of β-blockers and exercise training on cardiac structure and function, respectively, as well as overall functional capacity in a genetic model of sympathetic hyperactivity-induced heart failure in mice (α2A/α2CArKO). α2A/α2CArKO and their wild-type controls were studied for 2 months, from 3 to 5 months of age. Mice were randomly assigned to control (N = 45), carvedilol-treated (N = 29) or exercise-trained (N = 33) groups. Eight weeks of carvedilol treatment (38 mg/kg per day by gavage) or exercise training (swimming sessions of 60 min, 5 days/week) were performed. Exercise capacity was estimated using a graded treadmill protocol and HR was measured by tail cuff. Fractional shortening was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heart failure; Exercise training; Carvedilol treatment; Ventricular function; Cardiac remodeling; Α2A/α2CArKO mice.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900012

Loss of resting bradycardia with detraining is associated with intrinsic heart rate changes
Provedor de dados: 56
Autores: Evangelista,F.S.; Martuchi,S.E.D.; Negrão,C.E.; Brum,P.C.
The mechanisms underlying the loss of resting bradycardia with detraining were studied in rats. The relative contribution of autonomic and non-autonomic mechanisms was studied in 26 male Wistar rats (180-220 g) randomly assigned to four groups: sedentary (S, N = 6), trained (T, N = 8), detrained for 1 week (D1, N = 6), and detrained for 2 weeks (D2, N = 6). T, D1 and D2 were treadmill trained 5 days/week for 60 min with a gradual increase towards 50% peak VO2. After the last training session, D1 and D2 were detrained for 1 and 2 weeks, respectively. The effect of the autonomic nervous system in causing training-induced resting bradycardia and in restoring heart rate (HR) to pre-exercise training level (PET) with detraining was examined indirectly after...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Exercise training; Cardiac autonomic balance; Heart rate; Peak oxygen uptake; Detraining.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700018

Duration-controlled swimming exercise training induces cardiac hypertrophy in mice
Provedor de dados: 56
Autores: Evangelista,F.S.; Brum,P.C.; Krieger,J.E.
Exercise training associated with robust conditioning can be useful for the study of molecular mechanisms underlying exercise-induced cardiac hypertrophy. A swimming apparatus is described to control training regimens in terms of duration, load, and frequency of exercise. Mice were submitted to 60- vs 90-min session/day, once vs twice a day, with 2 or 4% of the weight of the mouse or no workload attached to the tail, for 4 vs 6 weeks of exercise training. Blood pressure was unchanged in all groups while resting heart rate decreased in the trained groups (8-18%). Skeletal muscle citrate synthase activity, measured spectrophotometrically, increased (45-58%) only as a result of duration and frequency-controlled exercise training, indicating that endurance...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Exercise training; Swimming; Cardiac hypertrophy; Mice; Myocardium.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200018

Effects of losartan combined with exercise training in spontaneously hypertensive rats
Provedor de dados: 56
Autores: Azevedo,L.F.; Brum,P.C.; Mattos,K.C.; Junqueira,C.M.; Rondon,M.U.P.B.; Barretto,A.C.P.; Negrao,C.E.
We investigate whether combined treatment with losartan, an angiotensin II receptor blocker, and exercise training (ET) in spontaneously hypertensive rats (SHR) would have an additive effect in reducing hypertension and improving baroreflex sensitivity when compared with losartan alone. Male SHR (8 weeks old) were assigned to 3 groups: sedentary placebo (SP, N = 16), sedentary under losartan treatment (SL, N = 11; 10 mg kg-1 day-1, by gavage), and ET under losartan treatment (TL, N = 10). ET was performed on a treadmill 5 days/week for 60 min at 50% of peak VO2, for 18 weeks. Blood pressure (BP) was measured with a catheter inserted into the carotid artery, and cardiac output with a microprobe placed around the ascending aorta. The baroreflex control of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Spontaneously hypertensive rats; Exercise training; Losartan; Baroreflex sensitivity.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001100018

Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function
Provedor de dados: 56
Autores: Brum,P.C.; Bacurau,A.V.N.; Medeiros,A.; Ferreira,J.C.B.; Vanzelli,A.S.; Negrão,C.E.
Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heart failure; Exercise training; Sympathetic hyperactivity; Ventricular function; Cardiac remodeling; Skeletal myopathy.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900002

Lactate-upregulation of lactate oxidation complex-related genes is blunted in left ventricle of myocardial infarcted rats
Provedor de dados: 56
Autores: Gabriel-Costa,D.; Cunha,T.F.; Paixão,N.A.; Fortunato,R.S.; Rego-Monteiro,I.C.C.; Barreto-Chaves,M.L.M.; Brum,P.C.
Lactate modulates the expression of lactate oxidation complex (LOC)-related genes and cardiac blood flow under physiological conditions, but its modulatory role remains to be elucidated regarding pathological cardiac stress. The present study evaluated the effect of lactate on LOC-related genes expression and hemodynamics of hearts submitted to myocardial infarction (MI). Four weeks after MI or sham operation, isolated hearts of male Wistar rats were perfused for 60 min with Na+-lactate (20 mM). As expected, MI reduced cardiac contractility and relaxation with no changes in perfusion. The impaired cardiac hemodynamics were associated with increased reactive oxygen species (ROS) levels (Sham: 19.3±0.5 vs MI: 23.8±0.3 µM), NADPH oxidase (NOX) activity (Sham:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lactate; Lactate oxidation complex; Myocardial infarction; Gene expression; Perfusion pressure; Oxidative stress.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001100605

The decreased oxygen uptake during progressive exercise in ischemia-induced heart failure is due to reduced cardiac output rate
Provedor de dados: 56
Autores: Rolim,N.P.L.; Mattos,K.C.; Brum,P.C.; Baldo,M.V.C.; Middlekauff,H.R.; Negrão,C.E.
We tested the hypothesis that the inability to increase cardiac output during exercise would explain the decreased rate of oxygen uptake (VO2) in recent onset, ischemia-induced heart failure rats. Nine normal control rats and 6 rats with ischemic heart failure were studied. Myocardial infarction was induced by coronary ligation. VO2 was measured during a ramp protocol test on a treadmill using a metabolic mask. Cardiac output was measured with a flow probe placed around the ascending aorta. Left ventricular end-diastolic pressure was higher in ischemic heart failure rats compared with normal control rats (17 ± 0.4 vs 8 ± 0.8 mmHg, P = 0.0001). Resting cardiac index (CI) tended to be lower in ischemic heart failure rats (P = 0.07). Resting heart rate (HR)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heart failure; Oxygen uptake rate; Cardiac index; Coronary ligation; Ischemia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200018

The acute effects of strength, endurance and concurrent exercises on the Akt/mTOR/p70S6K1 and AMPK signaling pathway responses in rat skeletal muscle
Provedor de dados: 56
Autores: Souza,E.O.de; Tricoli,V.; Bueno Junior,C.; Pereira,M.G.; Brum,P.C.; Oliveira,E.M.; Roschel,H.; Aoki,M.S.; Urginowitsch,C.
The activation of competing intracellular pathways has been proposed to explain the reduced training adaptations after concurrent strength and endurance exercises (CE). The present study investigated the acute effects of CE, strength exercises (SE), and endurance exercises (EE) on phosphorylated/total ratios of selected AMPK and Akt/mTOR/p70S6K1 pathway proteins in rats. Six animals per exercise group were killed immediately (0 h) and 2 h after each exercise mode. In addition, 6 animals in a non-exercised condition (NE) were killed on the same day and under the same conditions. The levels of AMPK, phospho-Thr172AMPK (p-AMPK), Akt, phospho-Ser473Akt (p-Akt), p70S6K1, phospho-Thr389-p70S6K1(p-p70S6K1), mTOR, phospho-Ser2448mTOR (p-mTOR), and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Strength exercise; Concurrent training; Cell signaling; AMPK.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400343