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Linkage disequilibrium and diversity for three genomic regions in Azoreans and mainland Portuguese
Provedor de dados: Genetics and Molecular Biology
Autores: Branco,Claudia C.; Pacheco,Paula R.; Cabrol,Ester; Cabral,Rita; Vicente,Astrid M.; Mota-Vieira,Luisa.
Studies on linkage disequilibrium (LD) across the genome and populations have been used in recent years with the main objective of improving gene mapping of complex traits. Here, we characterize the patterns of genetic diversity of HLA loci and evaluate LD (D') extent in three genomic regions: Xq13.3, NRY and HLA. In addition, we examine the distribution of DXS1225-DXS8082 haplotype diversity in Azoreans and mainland Portuguese. Allele distribution has demonstrated that the São Miguel population is genetically very diverse; haplotype analysis revealed 100% discriminatory power for X- and Y-markers and 94.3% for HLA markers. Standardized multiallelic D' in these three genomic regions shows values lower than 0.33, thereby suggesting there is no extensive LD...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Linkage disequilibrium; X-chromosome; Y-chromosome; HLA; São Miguel; Azores.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200003