Consulta: creatorFacets:"Campbell,O."
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Antiretroviral agents and acid-base balance at delivery of the neonate
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: El-Beitune,P.; Duarte,G.; Morais,E.N. de; Campbell,O.; Spara-Gadelha,P.; Mauad-Filho,F.; Quintana,S.M.; Rodrigues,L.C.
Limited evidence is available regarding antiretroviral (ARV) safety for uninfected infants exposed to these drugs in utero. Our objective was to determine if ARV administered to pregnant women is associated with decreasing umbilical arterial pH and base excess in uninfected infants. A prospective study was conducted on 57 neonates divided into three groups: ZDV group, born to mothers taking zidovudine (N = 20), triple therapy (TT) group, born to mothers taking zidovudine + lamivudine + nelfinavir (N = 25), and control group (N = 12), born to uninfected mothers. Umbilical cord blood was used to determine umbilical artery gases. A test was performed to calculate the sample by comparing means by the unpaired one-tailed t-test, with a = 0.05 and ß = 20%,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Infant toxicity; Pregnancy; Umbilical arterial pH; Apgar scores.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700010