Consulta: creatorFacets:"Castelo,Adauto"
Registros recuperados: 8
Data/hora: 09/06/2024 08:29:57

Human Papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Levi,José E.; Fink,Maria C.S.; Canto,Cynthia L.M.; Carretiero,Nadily; Matsubara,Regina; Linhares,Iara; Dores,Gérson B. das; Castelo,Adauto; Segurado,Aluísio; Uip,David E.; Eluf Neto,José.
HIV-infected women from São Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD4+ cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women (64.5%). Twenty (7.5%) women were infected by one or more low-risk viruses, 89 (33%) by one or more high-risk viruses, and 64 (24%) harbored at least one HPV type from each risk group. Abnormal smears were observed in 19% of the patients, though there were no invasive carcinomas. Severely immunosuppressed patients (CD4/µL &lt;100) were at the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human Papillomavirus; Cervical intraepithelial neoplasia; HIV-infected women; Viral load; AIDS.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300005

High prevalence of hepatitis C infection in a Brazilian prison: identification of risk factors for infection
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Guimarães,Thaís; Granato,Celso F. H.; Varella,Drauzio; Ferraz,Maria Lúcia G.; Castelo,Adauto; Kallás,Esper Georges.
Hepatitis C virus (HCV) causes infectious hepatitis worldwide. It is transmitted mainly by blood products and sharing of intravenous paraphernalia during illicit drug use. High prevalence rates have been described among specific groups considered to be at higher risk for HCV infection, including prison inmates. The objectives of this study were: to determine the HCV seroprevalence among inmates of Casa de Detenção de São Paulo; to identify risk factors for HCV infection; and to compare the seroprevalence of HCV to other blood borne or sexually transmitted diseases. From December, 1993, to January, 1994, a total of 779 inmates were interviewed to collect information on sociodemographic status, sexual behavior, and past experience with illicit drugs. Blood...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; Seroprevalence; Prison; Risk factor.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300002

Seroprevalence of hepatitis E virus in chronic hepatitis C in Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Bricks,Guilherme; Senise,Jorge Figueiredo; Pott Junior,Henrique; Grandi,Giuliano; Passarini,Amanda; Caldeira,Débora Bellini; Carnaúba Junior,Dimas; Moraes,Hamilton Antonio Bonilha de; Granato,Celso Franscisco Hernandes; Castelo,Adauto.
ABSTRACT  Background and aims: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors.  Methods: A total of 618 patients chronically infected with hepatitis C virus from three reference centers of São Paulo, Brazil were included. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA).  Results: Out of the 618 patients tested, 10.2% turned out positive for anti-HEV IgG (95% CI 8.0–12.8%)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis E virus; Hepatitis C virus; Brazil; Seroprevalence.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200085

Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Moreira,Marina; Freitas,Marise R.; Martins,Sinaida T.; Castelo,Adauto; Medeiros,Eduardo Alexandrino Servolo.
Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in most Brazilian Hospitals, and there are few studies which show the efficacy of control measures in such situations. This study evaluated intensive care unit (ICU) patients, in two years divided in control, intervention and post-intervention group. Intervention measures: hands-on educational programs for healthcare workers; early identification of MRSA infected or colonized patients, labeled with a bed-identification tag for contact isolation; nasal carriers, patients, and healthcare professionals treated with topical mupirocin for five days. The hospital infection rates in the control period were compared to the ones in the post-intervention period. Hospital infection rates were found by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Methicillin-resistant Staphylococcus aureus; Intensive care unit infections.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100015

Prevalence of IFNL3 gene polymorphism among blood donors and its relation to genomic profile of ancestry in Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Rizzo,Silvia Renata Cornelio Parolin; Gazito,Diana; Pott-Junior,Henrique; Latini,Flavia Roche Moreira; Castelo,Adauto.
ABSTRACT The recent development of interferon-free regimens based on direct-acting antivirals for the treatment of chronic hepatitis C virus infection has benefited many but not all patients. Some patients still experience treatment failure, possibly attributed to unknown host and viral factors, such as IFNL3 gene polymorphism. The present study assessed the prevalence of rs12979860-CC, rs12979860-CT, and rs12979860-TT genotypes of the IFNL3 gene, and its relationship with ancestry informative markers in 949 adult Brazilian healthy blood donors. Race was analyzed using ancestry informative markers as a surrogate for ancestry. IFNL3 gene was genotyped using the ABI TaqMan single nucleotide polymorphisms genotyping assays. The overall frequency of...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Ancestry informative markers; Chronic hepatitis C virus infection; Direct-acting antivirals; Single nucleotide polymorphisms.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600619

The application of latent class analysis for diagnostic test validation of chronic Trypanosoma cruzi infection in blood donors
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Langhi Junior,Dante M.; Bordin,José O.; Castelo,Adauto; Walter,Stephen D.; Moraes-Souza,Hélio; Stumpf,Robert J.
The main strategy to prevent transfusion-associated Chagas' disease is the identification of T. Cruzi-infected blood donors by serological screening tests, however there is no perfect serological gold standard. We evaluated an enzyme immunoassay (EIA), an indirect hemaglutination (IHA), and an indirect immunofluorescence (IIF) test for detecting T. Cruzi antibodies in Brazilian blood donors. The results were submitted to latent class analysis, and a radioimmunopreciptation (RIPA) test was performed on repeatedly positive samples. Among 1951 donors, 11 (0.56%) were positive by EIA, 6 (0.31%) by IHA and 16 (0.82%) by IIF. Six samples were positive with all tests, while 4 reacted with EIA and IIF. The RIPA was positive in 6 (75.0%), 7 (66.6%), and 4 (54.0%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chaga's disease; Blood donors; Diagnostic test; Latent class analysis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400005

Previous hepatitis E virus infection, cirrhosis and insulin resistance in patients with chronic hepatitis C
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Bricks,Guilherme; Senise,Jorge Figueiredo; Pott-Jr,Henrique; Grandi,Giuliano; Carnaúba-Jr,Dimas; Moraes,Hamilton Antonio Bonilha de; Granato,Celso Franscisco Hernandes; Castelo,Adauto.
ABSTRACT  Background: Hepatitis E virus (HEV) infection in patients with pre-existing liver disease has shown high morbidity and lethality. The consequences of HEV superinfection in patients with chronic hepatitis C virus (HCV) infection are not fully understood. This study aimed to evaluate the association between the presence of anti-HEV antibodies, liver cirrhosis, and insulin resistance.  Methods: A total of 618 patients chronically infected with HCV were included from three reference centers for viral hepatitis in São Paulo, Brazil. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA).  Results: The seroprevalence of anti-HEV in patients with cirrhosis was significantly higher than in patients without...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis E virus; Hepatitis C virus; Liver cirrhosis; Insulin resistance.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100045

Staphylococcus aureus bacteremia: comparison of two periods and a predictive model of mortality
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Conterno,Lucieni de Oliveira; Wey,Sérgio Barsanti; Castelo,Adauto.
Staphylococcus aureus is an important pathogen causing bacteremia, primarily affecting hospitalized patients. We studied the epidemiology of S. aureus bacteremia, comparing two periods (early and mid 1990s) and developed a predictive model of mortality. A nested case-control was done. All 251 patients over 14 years old with positive blood cultures for S. aureus were selected. MRSA (methicillin resistant S. aureus) was isolated in 63% of the cases. When comparing the two periods MRSA community-acquired bacteremia increased from 4% to 16% (p=0.01). There was no significant difference in the mortality rate between the two periods (39% and 33%, p=0.40). Intravascular catheters provoked 24% of the cases of bacteremia and were associated with the lowest rate of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Bacteremia; Mortality.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600004