Consulta: creatorFacets:"Chippaux,Jean-Philippe"
Registros recuperados: 14
Data/hora: 09/06/2024 04:06:15

Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
Provedor de dados: 80
Autores: Chippaux,Jean-Philippe; Boyer,Leslie V; Alagón,Alejandro.
Background Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. Methods We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. Results Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ebola; Epidemics; Immunotherapy; Prophylaxis; Africa.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100203

Ethnomedicinal plants used for snakebite treatments in Ethiopia: a comprehensive overview
Provedor de dados: 80
Autores: Yirgu,Abraham; Chippaux,Jean-Philippe.
Abstract Traditional medicine plays an important role in the daily lives of people living in rural parts of Ethiopia. Despite the fact that Ethiopia has a long history of using traditional medicinal plants as an alternative medicine source, there is no checklist compiling these plants used for snakebite treatment. This review collected and compiled available knowledge on and practical usage of such plants in the country. A literature review on medicinal plants used to treat snakebites was conducted from 67 journal articles, PhD dissertation and MSc theses available online. Data that summarize scientific and folk names, administration methods, plant portion used for treatment and method of preparation of recipes were organized and analyzed based on citation...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ethnobotany; Medicinal plant; Traditional treatment; Snakebite; Envenomation; Sub-Saharan Africa; Ethiopia.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100205

Delayed double reading of whole blood clotting test (WBCT) results at 20 and 30 minutes enhances diagnosis and treatment of viper evenomation
Provedor de dados: 80
Autores: Benjamin,Jordan Max; Chippaux,Jean-Philippe; Sambo,Bio Tamou; Massougbodji,Achille.
Abstract  Background The whole blood clotting test (WBCT) is a simple test of coagulation that is often used in the assessment, diagnosis, and therapeutic monitoring of snakebite patients in sub-Saharan Africa. WBCT requires only a clean glass tube and several milliliters of venous blood and is ideal for use in poorly equipped health centers throughout the rural areas where 95% of snakebites occur. However, questions surrounding the accuracy and reliability of the test remain unanswered due to variations in testing conditions and a lack of comparative research with which to validate them. This is the first study to evaluate WBCT results at both 20-min (WBCT20) and 30-min (WBCT30) reading times in the same group of snakebite patients.  Methods In order to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Africa; Snakebite; Echis; Envenomation; Whole blood clotting test; WBCT; Venom-induced consumption coagulopathy; Carpet viper; Saw-scaled viper.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100308

Epidemiology of snakebites in Kédougou region (eastern Senegal): comparison of various methods for assessment of incidence and mortality
Provedor de dados: 80
Autores: Lam,Absa; Camara,Bouna; Kane,Oumar; Diouf,Amadou; Chippaux,Jean-Philippe.
Abstract  Background  Although considered a public health issue in Senegal, the actual incidence and mortality from snakebite are not known. In the present study, an epidemiological survey was carried out in Kédougou region, southeastern Senegal, where envenomations, particularly by Echisocellatus, are frequent and severe.  Methods  Three sources of data were used: records from health centers and reports by health professionals; traditional healers; and household surveys.  Results  The annual incidence and mortality provided by health centers were 24.4 envenomations and 0.24 deaths per 100,000 population, respectively. The annual incidence recorded by traditional healers was 250 bites per 100,000 inhabitants, but the number of deaths was unknown. Finally,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epidemiology; Snakebite; Envenomation; Senegal; Incidence.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100307

Yellow fever in Africa and the Americas: a historical and epidemiological perspective
Provedor de dados: 80
Autores: Chippaux,Jean-Philippe; Chippaux,Alain.
Abstract Yellow fever was transported during the slave trade in the 15th and 16th centuries from Africa to the Americas where the virus encountered favorable ecological conditions that allowed creation of a sustainable sylvatic cycle. Despite effective vector control and immunization programs for nearly a century, yellow fever epidemics reemerged in many Latin American countries, particularly Brazil. The emergence or reemergence of vector-borne diseases encompasses many intricate factors. Yellow fever outbreaks occur if at least three conditions are fulfilled: the introduction of the virus into a non-immune human community, presence of competent and anthropophilic vectors and insufficiency of prevention and/or adequate management of the growing outbreak....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Yellow fever; Aedes aegypti; Haemagogus sp.; Sabethes sp. Vector; Arbovirus; Epidemiology; Brazil; Latin America; Africa.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100207

Use of antivenoms for the treatment of envenomation by Elapidae snakes in Guinea, Sub-Saharan Africa
Provedor de dados: 80
Autores: Baldé,Mamadou C; Chippaux,Jean-Philippe; Boiro,Mamadou Y; Stock,Roberto P; Massougbodji,Achille.
Background In Guinea Elapids are responsible for 20% of envenomations. The associated case fatality rate (CFR) ranged 15-27%, irrespective of treatment. Results We studied 77 neurotoxic envenomations divided in 3 groups: a set of patients that received only traditional or symptomatic treatments, and two other groups that received either 2 or 4 initial vials of Antivipmyn® Africa renewed as necessary. CFR was 27.3%, 15.4% and 17.6%, respectively. Although antivenom treatment was likely to reduce CFR, it didn’t seem to have an obvious clinical benefit for the patients, suggesting a low treatment efficacy. Mean delay to treatment or clinical stages were not significantly different between the patients who recovered and the patients who died, or between...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Elapid; Neurotoxins; Treatment; Antivenom; Guinea; Africa.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100304

A clinical trial protocol to treat massive Africanized honeybee (Apis mellifera) attack with a new apilic antivenom
Provedor de dados: 80
Autores: Barbosa,Alexandre Naime; Boyer,Leslie; Chippaux,Jean-Philippe; Medolago,Natalia Bronzatto; Caramori,Carlos Antonio; Paixão,Ariane Gomes; Poli,João Paulo Vasconcelos; Mendes,Mônica Bannwart; Santos,Lucilene Delazari dos; Ferreira Jr,Rui Seabra; Barraviera,Benedito.
Abstract  Background  Envenomation caused by multiple stings from Africanized honeybees Apis mellifera constitutes a public health problem in the Americas. In 2015, the Brazilian Ministry of Health reported 13,597 accidents (incidence of seven cases per 100,000 inhabitants) with 39 deaths (lethality of 0.25%). The toxins present in the venom, which include melittin and phospholipase A2, cause lesions in diverse organs and systems that may be fatal. As there has been no specific treatment to date, management has been symptomatic and supportive only.  Methods  In order to evaluate the safety and neutralizing capacity of a new apilic antivenom, as well as to confirm its lowest effective dose, a clinical protocol was developed to be applied in a multicenter,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Apis mellifera; Bee venom; Toxins; Envenomation; Heterologous serum; Apilic antivenom; Bee antivenom.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100309

Epidemiology of envenomations by terrestrial venomous animals in Brazil based on case reporting: from obvious facts to contingencies
Provedor de dados: 80
Autores: Chippaux,Jean-Philippe.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Envenomation; Snakes; Scorpions; Spiders; Caterpillars; Africanized bees; Brazil; Epidemiology.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100319

Outbreaks of Ebola virus disease in Africa: the beginnings of a tragic saga
Provedor de dados: 80
Autores: Chippaux,Jean-Philippe.
The tremendous outbreak of Ebola virus disease occurring in West Africa since the end of 2013 surprises by its remoteness from previous epidemics and dramatic extent. This review aims to describe the 27 manifestations of Ebola virus that arose after its discovery in 1976. It provides an update on research on the ecology of Ebola viruses, modes of contamination and human transmission of the disease that are mainly linked to close contact with an infected animal or a patient suffering from the disease. The recommendations to contain the epidemic and challenges to achieve it are reminded.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ebola; Outbreak; Virus; Hemorrhagic fever; Africa.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200209

The 6th international conference on envenomation by Snakebites and Scorpion Stings in Africa: a crucial step for the management of envenomation
Provedor de dados: 80
Autores: Chippaux,Jean-Philippe; Akaffou,Marc Hermann; Allali,Bernard Kouadio; Dosso,Mireille; Massougbodji,Achille; Barraviera,Benedito.
Abstract During the 6th International Conference on Envenomation by Snakebites and Scorpion Stings in Africa held in Abidjan, from 1 to 5 June 2015, the measures for the management of envenomation were discussed and new recommendations were adopted by the participants. The high incidence and severity of this affliction were confirmed by several studies conducted in African countries. The poor availability of antivenom, particularly because of the cost, was also highlighted. Some experiences have been reported, mainly those regarding the financial support of antivenom in Burkina Faso (more than 90 %) and Togo (up to 60 %) or the mandatory reporting of cases in Cameroon. Key recommendations concerned: improvement of epidemiological information based on case...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Envenomation; Antivenom; Epidemiology; Drug policy; Africa.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100101

Contribution of ultrasonography to the diagnosis of internal bleeding in snakebite envenomation
Provedor de dados: 80
Autores: Tchaou,Blaise Adelin; Tové,Kofi-Mensa Savi de; Tové,Yolande Sissinto-Savi de; Djomga,Aurélien Tchémaha C.; Aguemon,Abdou-Rahman; Massougbodji,Achille; Chippaux,Jean-Philippe.
Abstract  Background  In Africa, snakebite envenomations are frequently complicated by life-threatening hemorrhagic syndromes. The authors of the present study conducted a prospective analysis at the University Hospital of Parakou (north of Benin) for seven months (January 1 to July 31, 2014) to assess the contribution of ultrasonography to the diagnosis of internal bleedings and management of envenomation.  Methods  An ultrasound examination was performed in all patients with clinical envenomation regardless of its severity. The study involved 32 patients admitted to the ICU of the University Hospital of Parakou.  Results  The average age was 27 ± 13.9 years. The main signs of severity were: prolongation of clotting time (88 %), severe anemia (41 %),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Envenomation; Ultrasound; Internal bleeding; Hemoperitoneum; Hematoma.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100306

Snakebites notified to the poison control center of Morocco between 2009 and 2013
Provedor de dados: 80
Autores: Chafiq,Fouad; Hattimy,Faiçal El; Rhalem,Naima; Chippaux,Jean-Philippe; Soulaymani,Abdelmajid; Mokhtari,Abdelrhani; Soulaymani-Bencheikh,Rachida.
Abstract  Background  Snakebites cause considerable death and injury throughout the globe, particularly in tropical regions, and pose an important yet neglected threat to public health. In 2008, the Centre Anti Poison et de Parmacovigilance du Maroc (CAPM) started to set up a specific strategy for the control of snakebites that was formalized in 2012. The aim of the present study is to describe and update the epidemiological characteristics of snakebites notified to CAPM between 2009 and 2013.  Methods  This retrospective five-year study included all cases of snakebites notified to CAPM by mail or phone.  Results  During the study period, 873 snakebite cases were reported to CAPM, an average incidence of 2.65 cases per 100,000 inhabitants with 218 cases...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Snakebite; Envenomation; Viper; Morocco; Epidemiology.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100308

Snakebite envenomation turns again into a neglected tropical disease!
Provedor de dados: 80
Autores: Chippaux,Jean-Philippe.
Abstract: On June 9th, 2017 WHO categorized snakebite envenomation into the Category A of the Neglected Tropical Diseases. This new situation will allow access to new funding, paving the way for wider and deeper researches. It should also expand the accessibility of antivenoms. Let us hope that it also leads to cooperation among stakeholders, aiming at improving the management of snakebites in developing countries.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100802

The WHO strategy for prevention and control of snakebite envenoming: a sub-Saharan Africa plan
Provedor de dados: 80
Autores: Chippaux,Jean-Philippe; Massougbodji,Achille; Habib,Abdulrazaq G.
Abstract Snakebite is a critical public health issue in tropical countries, particularly in Africa, where 20% of snakebites globally occur. In 2017, the WHO added snakebite envenoming to the category A of neglected tropical diseases. In 2019, thanks to broad institutional and international NGO support, including strong mobilization of African experts and governments, WHO launched a strategy for prevention and control of snakebite envenoming with more ambitious goals. In sub-Saharan Africa, accessibility of antivenoms and symptomatic, adjuvant or replacement therapy is a priority. Several antivenoms are available but their evaluation has not been properly carried out and they remain expensive. To date, there are no manufacturers of antivenom in sub-Saharan...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Snakebite; Envenomation; Antivenom; Sub-Saharan Africa; Neglected tropical diseases; Control.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100101