Consulta: creatorFacets:"Chudzinski-Tavassi,A. M."
Registros recuperados: 2
Data/hora: 09/06/2024 04:30:30

rACLF, a recombinant snake venom metalloprotease, activates endothelial cells in vitro
Provedor de dados: 80
Autores: De Moraes,C. K.; Fritzen,M.; Chudzinski-Tavassi,A. M.; Selistre-de-Araújo,H. S.
Snake venom metalloproteases (SVMPs) comprise a family of snake venom toxins responsible for most of local and systemic effects observed during envenomation by snakes from the Viperidae family. The vascular system and more specifically the endothelium seem to be the preferential targets of these proteins. This work describes the effects of rACLF, a recombinant SVMP from Agkistrodon contortrix laticinctus on human umbilical vein endothelial cells (HUVECs) in vitro. Our results showed that rACLF activates HUVECs by the release of mediators involved in inflammation and hemostasis such as prostacyclin and interleukin-8. We also demonstrated that rACLF increased the expression of ICAM-I and decay accelerating factor (DAF). Moreover, rACLF protects the HUVECs...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: RACLF; Snake venom metalloprotease; Endothelial cells; Inflammation.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100009

Biochemical and biological properties of Lonomia obliqua bristle extract
Provedor de dados: 80
Autores: Chudzinski-Tavassi,A. M.; Carrijo-Carvalho,L. C.
Lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of Brazil. Patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. A consumptive coagulopathy was found to be the main cause of bleeding complications observed in patients after contact with L. obliqua. Studies revealed that L. obliqua caterpillar bristle extract (LOCBE) displays a procoagulant activity that leads to intravascular thrombin formation, resulting in a special form of disseminated intravascular coagulation (DIC). Fibrinolysis seems to be secondary to the fibrin production, since no direct fibrinolytic activity was found in LOCBE. Two procoagulant toxins, a factor X activator (Losac) and a prothrombin activator...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lonomia obliqua; Lonomia obliqua bristle extract; Hemorrhagic syndrome; Disseminated intravascular coagulation.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200002