Consulta: creatorFacets:"Codevilla,Cristiane Franco"
Registros recuperados: 6
Data/hora: 18/06/2024 02:57:27

A review of analytical methods for the determination of four new phosphodiesterase type 5 inhibitors in biological samples and pharmaceutical preparations
Provedor de dados: 60
Autores: Codevilla,Cristiane Franco; Castilhos,Tamara dos Santos; Bergold,Ana Maria.
The introduction of oral phosphodiesterase type 5 inhibitor therapy in 1998 revolutionized the treatment of erectile dysfunction. Erectile dysfunction is the most common sexual problem in men. It often has a profound effect on intimate relationships and quality of life. The analysis of pharmaceuticals is an important part of the drug development process as well as for routine analysis and quality control of commercial formulations. Whereas the determination of sildenafil citrate, vardenafil and tadalafil are well documented by a variety of methods, there are few publications about the determination of udenafil, lodenafil carbonate, mirodenafil and avanafil. The paper presents a brief review of the action mechanism, adverse effects, pharmacokinetics and the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Phosphodiesterase type 5 inhibitors/determination; Phosphodiesterase type 5 inhibitors/pharmaceutical preparations; Phosphodiesterase type 5 inhibitors/determination; Phosphodiesterase type 5 inhibitors/biological samples; Analytical methods; Erectile dysfunction.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100002

Development of alternative methods for the determination of raloxifene hydrochloride in tablet dosage form
Provedor de dados: 60
Autores: Salazar,Fernanda Rodrigues; Codevilla,Cristiane Franco; Meneghini,Leonardo; Bergold,Ana Maria.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Raloxifene/determination in tablets; High performance liquid chromatography/quantitative analysis; UV spectrophotometric method/quantitative analysis; Micellar capillary electrophoresis/ quantitative analysis; Stability-indicating methods.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200349

Improvement of the viability of probiotics (Lactobacillus acidophilus) by multilayer encapsulation
Provedor de dados: 65
Autores: Menezes,Maria Fernanda da Silveira Cáceres de; Silva,Thaiane Marques da; Etchepare,Mariana de Araújo; Fonseca,Bruna de Souza; Sonza,Vandré Pinto; Codevilla,Cristiane Franco; Barin,Juliano Smanioto; Silva,Cristiane de Bona da; Menezes,Cristiano Ragagnin de.
ABSTRACT:  This study produced pectin microcapsules containing Lactobacillus acidophilus by external ionic gelation, followed by the adsorption of whey protein and pectin to form multilayers. The viability of free and microencapsulated lactobacilli was evaluated after in vitro exposure to gastrointestinal conditions. They were also assessed by heat treatment, and stability was examined at -18 °C, 5 °C and 25 °C for 120 days. Exposure to different pHs, simulating passage through the gastrointestinal tract, showed that treatment of the microcapsules with only pectin (LA/P0) and with one and two layers of whey protein (treatments LA/P1 and LA/P3, respectively), were able to protect Lactobacillus acidophilus , with microcapsules increasing the release of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pectin; Whey protein concentrate; External ionic gelation.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900751

Physicochemical characterization and evaluation of in vitro and in vivo toxicity of goldenberry extract nanoemulsion
Provedor de dados: 65
Autores: Silva,Suelen Santos da; Bazana,Maiara Taís; Deus,Cassandra de; Machado,Marina Lopes; Cordeiro,Larissa Marafiga; Soares,Félix Alexandre Antunes; Libreloto,Daniele Rubert Nogueira; Rolim,Clarice Madalena Bueno; Menezes,Cristiano Ragagnin de; Codevilla,Cristiane Franco.
ABSTRACT:  Oil-in-water (O/W) nanoemulsion containing goldenberry extract was elaborated using a high-energy ultrasonic bath method. Physicochemical characterization of the formulation was carried out by determining pH, mean droplet diameter, polydispersity index (PDI) and zeta potential. Nanoemulsion toxicity was assessed using in vitro assays with tumor and non-tumor cell lines, and in vivo using Caenorhabditis elegans. The pH of the nanoemulsion was 3.84, the mean droplet diameter was 268 ± 7 nm, PDI 0.113 and zeta potential -13.94 mV. Results of the cytotoxicity assays employing non-tumor cells indicated that the extract associated or not with nanoemulsion maintained cell viability at different concentrations tested. In the assays using tumor lineage,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Physalis peruviana; Nanoemulsion; Citotoxicity; C. elegans.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000800754

Cytotoxicity and antioxidant activity of goldenberry extracts obtained with high intensity ultrasound
Provedor de dados: 65
Autores: Codevilla,Cristiane Franco; Tischer,Bruna; Gindri,Amanda Leitão; Nogueira-Librelotto,Daniele Rubert; Barin,Juliano Smanioto; Silva,Cristiane de Bona da; Rolim,Clarice Madalena Bueno; Zepka,Leila Queiroz; Menezes,Cristiano Ragagnin de.
ABSTRACT: The high intensity ultrasound-assisted extraction (HIU) is one of the most simple, quick and efficient techniques for the extraction of phenolic and other antioxidant compounds from plants. This is the first application of HIU for the extraction of these compounds from goldenberry fruit. The HIU and conventional extraction techniques showed similar results regarding to phenolic compounds and antioxidant capacity. However, the time required for HIU extraction (5min) was 24 times lower than conventional extraction (120min). Phenolic compounds reported were chlorogenic acid, caffeic acid and rutin. In vitro cytotoxicity assays were used for evaluation of extracts and the results showed that in a wide range of concentration, the extract maintains...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Goldenberry; Sonication; Antioxidant capacity; Cytotoxicity; High performance liquid chromatography.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000200752

Encapsulation of Lactobacillus acidophilus La-5 and Bifidobacterium Bb-12 by spray drying and evaluation of its resistance in simulated gastrointestinal conditions, thermal treatments and storage conditions
Provedor de dados: 65
Autores: Nunes,Graciele Lorenzoni; Motta,Mariana Heldt; Cichoski,Alexandre José; Wagner,Roger; Muller,Édson Irineu; Codevilla,Cristiane Franco; Silva,Cristiane de Bona da; Menezes,Cristiano Ragagnin de.
ABSTRACT: Lactobacillus acidophillus La-5 (ML) and Bifidobacterium Bb-12 (MB) microparticles were produced at different temperatures by spray dryer. The influence of different temperatures on the viability, encapsulation efficiency, water activity and moisture were evaluated. Microparticles that presented more viability were submitted to thermal resistance, gastrointestinal simulation, storage stability, morphology and particle size analyses. Drying temperature of 130°C showed higher encapsulation efficiency, 84.61 and 79.73% for Lactobacillus acidophillus (ML) and Bifidobacterium Bb-12 (MB) microparticles, respectively. In the evaluation of thermal resistance and gastrointestinal simulation, the microparticles of Lactobacillus acidophillus La-5 (ML)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Spray dryer; Viability; Probiotics.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000600751