Consulta: creatorFacets:"Coltau,M."
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Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation
Provedor de dados: 56
Autores: Puscas,I.; Coltau,M.; Gilau,L.; Pasca,R.; Domuta,G.; Baican,M.; Hecht,A.
We studied the relationship between alpha- and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. Kinetic studies were performed. Adrenergic agonists increased erythrocyte carbonic anhydrase as follows: adrenaline by 75%, noradrenaline by 68%, isoprenaline by 55%, and orciprenaline by 62%. The kinetic data indicated a non-competitive mechanism of action. In clinical studies carbonic anhydrase I from erythrocytes increased by 87% after noradrenaline administration, by 71% after orciprenaline and by 82% after isoprenaline. The increase in carbonic anhydrase I paralleled the increase in blood pressure. Similar results were obtained in vessel studies on piglet vascular smooth muscle. We believe...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adrenergic agonists; Carbonic anhydrase; Arterial blood pressure.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300007