Consulta: creatorFacets:"Corbel,M."
Registros recuperados: 1
Data/hora: 09/06/2024 01:07:38

Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury
Provedor de dados: 56
Autores: Corbel,M.; Boichot,E.; Lagente,V.
Acute lung injury is characterized by a severe disruption of alveolo-capillary structures and includes a variety of changes in lung cell populations. Evidence suggests the occurrence of rupture of the basement membranes and interstitial matrix remodeling during acute lung injury. The dynamic equilibrium of the extracellular matrix (ECM) under physiological conditions is a consequence of the balance between the regulation of synthesis and degradation of ECM components. Matrix metalloproteinases (MMPs) represent a group of enzymes involved in the degradation of most of the components of the ECM and therefore participate in tissue remodeling associated with pathological situations such as acute lung injury. MMP activity is regulated by proteolytic activation...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Matrix metalloproteinase; TIMPs; Acute lung injury; ARDS; LPS; Extracellular matrix.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700004