Consulta: creatorFacets:"Coute, Yohann"
Registros recuperados: 2
Data/hora: 08/06/2024 09:44:36

Evolution of gene dosage on the Z-chromosome of schistosome parasites
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Picard, Marion A. L.; Cosseau, Celine; Ferre, Sabrina; Quack, Thomas; Grevelding, Christoph G.; Coute, Yohann; Vicoso, Beatriz.
XY systems usually show chromosome-wide compensation of X-linked genes, while in many ZW systems, compensation is restricted to a minority of dosage-sensitive genes. Why such differences arose is still unclear. Here, we combine comparative genomics, transcriptomics and proteomics to obtain a complete overview of the evolution of gene dosage on the Z-chromosome of Schistosoma parasites. We compare the Z-chromosome gene content of African (Schistosoma mansoni and S. haematobium) and Asian (S. japonicum) schistosomes and describe lineage-specific evolutionary strata. We use these to assess gene expression evolution following sex-linkage. The resulting patterns suggest a reduction in expression of Z-linked genes in females, combined with upregulation of the Z...
Tipo: Text
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00454/56588/71845.pdf

Outer membrane vesicles are vehicles for the delivery of Vibrio tasmaniensis virulence factors to oyster immune cells
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Vanhove, Audrey; Duperthuy, Marylise; Charriere, Guillaume; Le Roux, Frederique; Goudenege, David; Gourbal, Benjamin; Kieffer-jaquinod, Sylvie; Coute, Yohann; Wai, Sun Nyunt; Destoumieux-garzon, Delphine.
Vibrio tasmaniensis LGP32, a facultative intracellular pathogen of oyster haemocytes, was shown here to release outer membrane vesicles (OMVs) both in the extracellular milieu and inside haemocytes. Intracellular release of OMVs occurred inside phagosomes of intact haemocytes having phagocytosed few vibrios as well as in damaged haemocytes containing large vacuoles heavily loaded with LGP32. The OMV proteome of LGP32 was shown to be rich in hydrolases (25%) including potential virulence factors such as proteases, lipases, phospholipases, haemolysins and nucleases. One major caseinase/gelatinase named Vsp for vesicular serine protease was found to be specifically secreted through OMVs in which it is enclosed. Vsp was shown to participate in the virulence...
Tipo: Text
Ano: 2015
URL: http://archimer.ifremer.fr/doc/00199/31009/29459.pdf