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Early and late molecular and morphologic changes that occur during the in vitro transformation of Trypanosoma cruzi metacyclic trypomastigotes to amastigotes
Provedor de dados: Biological Research
Autores: CONTRERAS,VÍCTOR T; NAVARRO,MARÍA C; DE LIMA,ANA R; DURAN,FRANCY; ARTEAGA,ROSA; FRANCO,YUNAIMY.
The amastigogenesis primary of T. cruzi occurs naturally when metacyclic trypomastigotes transform into amastigotes within the cells of the mammalian host. The in vitro study of the macromolecular changes that occur over several days during the transformation process should provide significant indications of how the parasite adapts to the mammalian host environment. We show here that metacyclic trypomastigotes pre-incubated at 37&amp;deg; C in a protein-rich medium reach a high degree of transformation to amastigotes when re-incubated in the fresh medium. Giemsa-stained smears show that during the pre-incubation phase, the metacyclic trypomastigotes undergo lengthening at the posterior end and a thinning out of the entire body. SDS-PAGE analysis of...
Tipo: Journal article
Palavras-chave: Amastigogenesis; Differentiation; Macromolecular changes; Metacyclic trypomastigotes; Trypanosoma cruzi.
Ano: 2002
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000100008