Consulta: creatorFacets:"DosReis,G.A."
Registros recuperados: 2
Data/hora: 03/06/2024 04:23:14

Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: DosReis,G.A.
Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective vaccines. During the acute phase, parasites replicate extensively and release immunomodulatory molecules that delay parasite-specific responses mediated by T cells. This immune evasion allows the parasite to spread in the host. In the chronic phase, parasite evasion relies on its replication strategy of hijacking the TGF-β signaling pathway involved in inflammation and tissue regeneration. In this article, the mechanisms of immune evasion described for T. cruzi...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; T cells; GPI-anchors; TGF-β; Mucin; Apoptosis.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200001

Apoptosis in parasites and parasite-induced apoptosis in the host immune system: a new approach to parasitic diseases
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Barcinski,M.A.; DosReis,G.A.
Apoptosis, a form of programmed cell death (PCD), has been described as essential for normal organogenesis and tissue development, as well as for the proper function of cell-renewal systems in adult organisms. Apoptosis is also pivotal in the pathogenesis of several different diseases. In this paper we discuss, from two different points of view, the role of apoptosis in parasitic diseases. The description of apoptotic death in three different species of heteroxenic trypanosomatids is reviewed, and considerations on the phylogenesis of apoptosis and on the eventual role of PCD on their mechanism of pathogenesis are made. From a different perspective, an increasing body of evidence is making clear that regulation of host cell apoptosis is an important factor...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Apoptosis; Parasites; Host cells; Host immune system; Programmed cell death; Trypanosomatids.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400003