Consulta: creatorFacets:"Dräger,A.M."
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New strategies in hematopoietic stem cell transplantation: G-CSF-mobilized unprocessed whole blood
Provedor de dados: 56
Autores: Dräger,A.M.; Ossenkoppele,G.J.; Jonkhoff,A.R.; Schuurhuis,G.J.; Huijgens,P.C.
Transplantation of mobilized peripheral blood stem cells (PBSC) for rescue of bone marrow function after high-dose chemo-/radiotherapy is widely used in hematologic malignancies and solid tumors. Mobilization of stem cells to the peripheral blood can be achieved by cytokine treatment of the patients. The main advantage of autologous PBSC transplantation over bone marrow transplantation is the faster recovery of neutrophil and platelet counts. The threshold number of PBSC required for adequate rescue of bone marrow is thought to be about 2 x 106 CD34+ cells/kg, if the stem cells are collected by leukapheresis and subsequently cryopreserved. We show that this critical number could be further reduced to as few as 0.2 x 106 cells/kg. In 30 patients with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hematopoietic stem cells; Transplantation; Cytokines; G-CSF; Lymphoma; Multiple myeloma.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100006