Consulta: creatorFacets:"FERREIRA,PAULO MICHEL PINHEIRO"
Registros recuperados: 3
Data/hora: 18/06/2024 02:34:27

Cytotoxic and toxicological effects of phthalimide derivatives on tumor and normal murine cells
Provedor de dados: 42
Autores: FERREIRA,PAULO MICHEL PINHEIRO; COSTA,PATRICIA MARÇAL DA; COSTA,ARINICE DE MENEZES; LIMA,DAISY JEREISSATI BARBOSA; DRUMOND,RENATA ROSADO; SILVA,JURANDY DO NASCIMENTO; MOREIRA,DIOGO RODRIGO DE MAGALHÃES; OLIVEIRA FILHO,GEVÂNIO BEZERRA DE; FERREIRA,JAMILE MAGALHÃES; QUEIROZ,MARIA GORETTI RODRIGUES DE; LEITE,ANA CRISTINA LIMA; PESSOA,CLÁUDIA.
Eleven phthalimide derivatives were evaluated with regards to their antiproliferative activity on tumor and normal cells and possible toxic effects. Cytotoxic analyses were performed against murine tumors (Sarcoma 180 and B-16/F-10 cells) and peripheral blood mononuclear cells (PBMC) using MTT and Alamar Blue assays. Following, the investigation of cytotoxicity was executed by flow cytometry analysis and antitumoral and toxicological potential by in vivo techniques. The molecules 3b, 3c, 4 and 5 revealed in vitro cytotoxicity against Sarcoma 180, B-16/F-10 and PBMC. Since compound 4 was the most effective derivative, it was chosen to detail the mechanism of action after 24, 48 and 72 h exposure (22.5 and 45 µM). Sarcoma 180 cells treated with compound 4...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytotoxicity; Histological alterations; Murine cells; Phthalimide derivatives; Sarcoma 180.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100313

Action of Aqueous Extracts of Phyllanthus niruri L. (Euphorbiaceae) leaves on Meristematic Root Cells of Allium cepa L.
Provedor de dados: 42
Autores: NEVES,ERASMOVLANE S.B.; FERREIRA,PAULO MICHEL PINHEIRO; LIMA,LEONARDO H.G.M.; PERON,ANA PAULA.
This study aimed to evaluate the effects of aqueous extracts of dried Phyllanthus niruri L. (stonebreaker) leaves on Allium cepa L. root meristem cells at four concentrations, 0.02 (usual concentration), 0.04, 0.06 and 0.08mg/mL and exposure times of 24 and 48 hours. For each concentration we used a group of five onion bulbs that were first embedded in distilled water and then transferred to their respective concentrations. The radicles were collected and fixed in acetic acid (3:1) for 24 hours. The slides were prepared by the crushing technique and stained with 2% acetic orcein. Cells were analyzed throughout the cell cycle, totaling 5000 for each control and exposure time. The calculated mitotic indices were subjected to the Chi-squared statistical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Medicinal plant; Stonebreaker; Cell division; Cellular aberrations; Allium cepa.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301131

Counteracting effects on free radicals and histological alterations induced by a fraction with casearins
Provedor de dados: 42
Autores: ARAÚJO,ÉVERTON JOSÉ FERREIRA DE; OLIVEIRA,GUILHERME ANTÔNIO LOPES DE; SOUSA,LÍVIA QUEIROZ DE; BOLZANI,VANDERLAN DA SILVA; CAVALHEIRO,ALBERTO JOSÉ; TOME,ADRIANA DA ROCHA; PERON,ANA PAULA; SANTOS,ANDRÉ GONZAGA DOS; CITÓ,ANTONIA MARIA DAS GRAÇAS LOPES; PESSOA,CLÁUDIA; FREITAS,RIVELILSON MENDES DE; FERREIRA,PAULO MICHEL PINHEIRO.
ABSTRACTCasearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis-clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. sylvestrisand histological changes on the central nervous system and livers of Mus musculus mice. Firstly, in vitro studies (0.9, 1.8, 3.6, 5.4 and 7.2 μg/mL) revealed EC50 values of 3.7, 6.4 and 0.16 µg/mL for nitrite, hydroxyl radical and TBARS levels, respectively. Secondly, FC (2.5, 5, 10 and 25 mg/kg/day) was intraperitoneally...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clerodane diterpenes; Casearia sylvestris; Antioxidant; Morphological changes; Toxicity.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000401791