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G2 repair and chromosomal damage in lymphocytes from workers occupationally exposed to low-level ionizing radiation
Provedor de dados: 48
Autores: PINCHEIRA,J; LÓPEZ,I; SANHUEZA,S; FERRUZ,P; NAVRRETE,MH; SANTOS,MJ; LÓPEZ-SÁEZ,JF.
The effect of the G2 repair of chromosomal damage in lymphocytes from workers exposed to low levels of X- or g-rays was evaluated. Samples of peripheral blood were collected from 15 radiation workers, 20 subjects working in radiodiagnostics, and 30 healthy control donors.  Chromosomal aberrations (CA) were evaluated by scoring the presence of chromatid and isochromatid breaks, dicentric and ring chromosomes in lymphocytes with/without 5mM caffeine plus 3mM-aminobenzamide (3-AB) treatment during G2.  Our results showed that the mean value of basal aberrations in lymphocytes from exposed workers was higher than in control cells (p&amp;lt; 0.001). The chromosomal damage in G2, detected with caffeine plus 3-AB treatment was higher than the basal damage...
Tipo: Journal article
Palavras-chave: Chromosome aberrations ionizing radiation; G2 repair; Human lymphocytes; Occupational exposure.
Ano: 1999
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97601999000400009