Consulta: creatorFacets:"Ferrario,C.M."
Registros recuperados: 2
Data/hora: 10/06/2024 12:19:09

Bi-directional actions of estrogen on the renin-angiotensin system
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Brosnihan,K.B.; Senanayake,P.S.; Li,P.; Ferrario,C.M.
Estrogen stimulates the renin-angiotensin system by augmenting both tissue and circulating levels of angiotensinogen and renin. We show, however, that angiotensin converting enzyme (ACE) activity in the circulation and in tissues is reduced in two animal models of postmenopausal chronic hormone replacement. We observed a reduction of ACE activity in association with a significant increase in plasma angiotensin I (Ang I) and hyperreninemia in ovariectomized monkeys treated with Premarin (conjugated equine estrogen) replacement for 30 months. Plasma angiotensin II (Ang II) levels were not increased in monkeys treated with estrogen, suggesting that the decrease in ACE curtailed the formation of the peptide. The Ang II/Ang I ratio, an in vivo index of ACE...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Renin; Angiotensin converting enzyme; Angiotensin peptides; Angiotensin receptors; Bradykinin; Nitric oxide; Kinins; Vasodilation; Hormone replacement.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400001

Antihypertensive effects of angiotensin-(1-7)
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Chappell,M.C.; Iyer,S.N.; Diz,D.I.; Ferrario,C.M.
Accumulating evidence suggests that angiotensin-(1-7) (Ang-(1-7)) is an important component of the renin-angiotensin system and that the actions of the peptide may either contribute to or oppose those of Ang II. Ang-(1-7) can be converted directly from Ang I bypassing prerequisite formation of Ang II. Formation of Ang-(1-7) is under the control of at least three endopeptidases depending on the tissue compartment and include neprilysin, thimet oligopeptidase and prolyl oligopeptidase. Both neprilysin and thimet oligopeptidase are also involved in the metabolism of bradykinin and the atrial natriuretic peptide. Moreover, recent studies suggest that in addition to Ang I and bradykinin, Ang-(1-7) is an endogenous substrate for angiotensin converting enzyme....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Angiotensin-(1-7); Angiotensin II; Hypertension.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000900014