Consulta: creatorFacets:"Ferraz,Mariane Avante"
Registros recuperados: 2
Data/hora: 02/06/2024 04:49:32

Lack of association among TNF-α gene expression, -308 polymorphism (G &amp;gt; A) and virulence markers of Helicobacter pylori
Provedor de dados: 80
Autores: Zabaglia,Luanna Munhoz; Ferraz,Mariane Avante; Pereira,Weendelly Nayara; Orcini,Wilson Aparecido; Labio,Roger Willian de; Caleman Neto,Agostinho; Wisnieski,Fernanda; Oliveira,Juliana Garcia de; Smith,Marilia de Arruda Cardoso; Payão,Spencer Luiz Marques; Rasmussen,Lucas Trevizani.
Abstract  Background  Tumor necrosis factor plays a critical role in the pathogenesis of gastric diseases such as gastric cancer, and an abnormal inflammatory response has frequently been observed in dyspeptic patients. Helicobacter pylori infection can induce a gastric mucosal inflammatory response that may be influenced by -308 (G &gt; A) polymorphisms and gene expression of theTNF-α gene.  Methods  One hundred and thirty-four gastric biopsy samples were collected from patients of both genders (61♂ and 73♀, mean age 40.3 ± 24.2 years) with gastric symptoms. The -308 (G &gt; A) polymorphism of TNF-α was characterized using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The expression level was measured using real-time...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: H. pylori; TNF-α Gene expression; Gastric cancer cagA.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100355

Association among H. pylori virulence markers dupA, cagA and vacA in Brazilian patients
Provedor de dados: 80
Autores: Pereira,Weendelly Nayara; Ferraz,Mariane Avante; Zabaglia,Luanna Munhoz; Labio,Roger William de; Orcini,Wilson Aparecido; Ximenez,João Paulo Bianchi; Caleman Neto,Agostinho; Payão,Spencer Luiz Marques; Rasmussen,Lucas Trevizani.
Background:Only a few Helicobacter pylori-infected individuals develop severe gastric diseases and virulence factors of H. pyloriappear to be involved in such clinical outcomes. Duodenal ulcer promoting gene A (dupA) is a novel virulence factor ofHelicobacter pylori that is associated with duodenal ulcer development and reduced risk for gastric carcinoma in some populations. The aims of the present study were to determine the presence ofdupA gene and evaluate the association amongdupA and other virulence factors includingcagA and vacA in Brazilian patients. Gastric biopsies were obtained from 205 dyspeptic patients (100 children and 105 adults). DNA was extracted and analyzed for the presence of H. pylori and its virulence factors using the polymerase...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Helicobacter pylori; DupA; CagA; VacA; Gastroduodenal diseases; PCR.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200319