Consulta: creatorFacets:"Ferreira,C.J.S."
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Data/hora: 17/06/2024 14:39:14

Retinol-induced changes in the phosphorylation levels of histones and high mobility group proteins from Sertoli cells
Provedor de dados: 56
Autores: Moreira,J.C.F.; Dal-Pizzol,F.; Rocha,A.B.; Klamt,F.; Ribeiro,N.C.; Ferreira,C.J.S.; Bernard,E.A.
Chromatin proteins play a role in the organization and functions of DNA. Covalent modifications of nuclear proteins modulate their interactions with DNA sequences and are probably one of the multiple factors involved in the process of switch on/off transcriptionally active regions of DNA. Histones and high mobility group proteins (HMG) are subject to many covalent modifications that may modulate their capacity to bind to DNA. We investigated the changes induced in the phosphorylation pattern of cultured Wistar rat Sertoli cell histones and high mobility group protein subfamilies exposed to 7 µM retinol for up to 48 h. In each experiment, 6 h before the end of the retinol treatment each culture flask received 370 KBq/ml [32P]-phosphate. The histone and HMGs...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sertoli cells; Phosphorylation; Histones; High mobility group proteins; Retinol.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000300005