Consulta: creatorFacets:"GALARCE,GLORIA D"
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Data/hora: 04/06/2024 01:08:21

Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
Provedor de dados: 48
Autores: GALARCE,GLORIA D; FONCEA,ROCÍO E; EDWARDS,ANA M; PESSOA-MAHANA,HERNÁN; PESSOA-MAHANA,CARLOS D; EBENSPERGER,ROBERTO A.
This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents
Tipo: Journal article
Palavras-chave: Anti-inflammatory agents; Benzimidazoquinazoline derivatives; TNF-á inhibitors.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006