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CYP1A1, GSTM1, GSTT1 and GSTP1 polymorphisms in an Afro-Brazilian group
Provedor de dados: 74
Autores: Kvitko,Kátia; Gaspar,Pedro de Abreu; Torres,Martiela Ribeiro; Hutz,Mara H.
Gene polymorphisms involved in the metabolism of drugs and chemical carcinogens seem to be responsible for differences in the susceptibility of individuals to cancer, but genetic population studies are needed to characterize these polymorphisms in different ethnic populations. We investigated polymorphisms of the cytochrome P450 (CYP) gene CYP1A1 and the glutathione S-transferase (GSTs) genes GSTM1, GSTT1 and GSTP1 in a sample of Afro-Brazilians from the southern Brazilian city of Porto Alegre to verify if there were ethnic differences compared to the polymorphisms of the same genes in a previously described sample of Brazilians of European descent from the same city. The allele frequencies detected in the Afro-Brazilian population investigated in this...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: African; Brazilian; CYP1A1; European; GSTs; Porto Alegre.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000400006