Consulta: creatorFacets:"Gervásio,S.A."
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Data/hora: 10/06/2024 02:27:09

High prevalence of alpha-thalassemia among individuals with microcytosis and hypochromia without anemia
Provedor de dados: 56
Autores: Borges,E.; Wenning,M.R.S.C.; Kimura,E.M.; Gervásio,S.A.; Costa,F.F.; Sonati,M.F.
In order to determine the contribution of alpha-thalassemia to microcytosis and hypochromia, 339 adult outpatients seen at Unicamp University Hospital (with the exception of the Clinical Hematology outpatient clinics), who showed normal hemoglobin (Hb) levels and reduced mean corpuscular volume and mean corpuscular hemoglobin, were analyzed. Ninety-eight were Blacks (28.9%) and 241 were Caucasians (71.1%). In all cases, Hb A2 and F levels were either normal or low. The most common deletional and nondeletional forms of alpha-thalassemia [-alpha3.7, -alpha4.2, --MED, -(alpha)20.5, alphaHphIalpha, alphaNcoIalpha, &lt;FONT FACE="Symbol"&gt;aa&lt;/FONT&gt;NcoI and alphaTSAUDI] were investigated by PCR and restriction enzyme analyses. A total of 169 individuals...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alpha-thalassemia; Microcytosis; Hypochromia; Hemoglobinopathies; Brazilian population.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600009