Consulta: creatorFacets:"Gomes,F.C.A."
Registros recuperados: 3
Data/hora: 02/06/2024 17:30:24

Cross-talk between neurons and glia: highlights on soluble factors
Provedor de dados: 56
Autores: Gomes,F.C.A.; Spohr,T.C.L.S.; Martinez,R.; Moura Neto,V.
The development of the nervous system is guided by a balanced action between intrinsic factors represented by the genetic program and epigenetic factors characterized by cell-cell interactions which neural cells might perform throughout nervous system morphogenesis. Highly relevant among them are neuron-glia interactions. Several soluble factors secreted by either glial or neuronal cells have been implicated in the mutual influence these cells exert on each other. In this review, we will focus our attention on recent advances in the understanding of the role of glial and neuronal trophic factors in nervous system development. We will argue that the functional architecture of the brain depends on an intimate neuron-glia partnership.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neuron-glia interaction; Trophic factors; Astrocyte; Neuron; Nervous system.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500008

Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation
Provedor de dados: 56
Autores: Gomes,F.C.A.; Paulin,D.; Moura Neto,V.
Intermediate filament (IF) proteins constitute an extremely large multigene family of developmentally and tissue-regulated cytoskeleton proteins abundant in most vertebrate cell types. Astrocyte precursors of the CNS usually express vimentin as the major IF. Astrocyte maturation is followed by a switch between vimentin and glial fibrillary acidic protein (GFAP) expression, with the latter being recognized as an astrocyte maturation marker. Levels of GFAP are regulated under developmental and pathological conditions. Upregulation of GFAP expression is one of the main characteristics of the astrocytic reaction commonly observed after CNS lesion. In this way, studies on GFAP regulation have been shown to be useful to understand not only brain physiology but...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CNS; Astrocyte; Growth factors; Intermediate filaments; GFAP; Vimentin; GFAP gene.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500016

Regulatory roles of microtubule-associated proteins in neuronal morphogenesis. Involvement of the extracellular matrix
Provedor de dados: 56
Autores: Ramírez,G.; Alvarez,A.; Garcia-Abreu,J.; Gomes,F.C.A.; Moura-Neto,V.; Maccioni,R.B.
As a result of recent investigations, the cytoskeleton can be viewed as a cytoplasmic system of interconnected filaments with three major integrative levels: self-assembling macromolecules, filamentous polymers, e.g., microtubules, intermediate filaments and actin filaments, and supramolecular structures formed by bundles of these filaments or networks resulting from cross-bridges between these major cytoskeletal polymers. The organization of this biological structure appears to be sensitive to fine spatially and temporally dependent regulatory signals. In differentiating neurons, regulation of cytoskeleton organization is particularly relevant, and the microtubule-associated protein (MAP) tau appears to play roles in the extension of large neuritic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Extracellular matrix; Tau functions; Regulatory patterns; Neuronal morphogenesis.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500015