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Characterization of an alcoholic hepatic steatosis model induced by ethanol and high-fat diet in rats
Provedor de dados: Brazilian Archives of Biology and Technology
Autores: Souza,Carlos Eduardo Alves de; Stolf,Aline Maria; Dreifuss,Arturo Alejandro; Lívero,Francislaine dos Reis; Gomes,Liana de Oliveira; Petiz,Lyvia; Beltrame,Olair; Dittrich,Rosangela Locatelli; Telles,José Ederaldo Queiroz; Cadena,Sílvia Maria; Acco,Alexandra.
Alcoholic liver disease is characterized by a wide spectrum of liver damage, which increases when ethanol is associated with high-fat diets (HFD). This work aimed to establish a model of alcoholic hepatic steatosis (AHS) by using a combination of 10% ethanol and sunflower seeds as the source of HFD. Male rats received water or 10% ethanol and regular chow diet and/or HFD, which consisted of sunflower seeds. The food consumption, liquid intake and body weight of the rats were monitored for 30 days. After this period, blood was collected for biochemical evaluation, and liver samples were collected for histological, mitochondrial enzyme activity and oxidative stress analyses. Our results indicated that the combination of 10% ethanol and HFD induced micro- and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ethanol; Alcoholic hepatic steatosis; High-fat diet; Sunflower seeds; Mitochondria.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000300367