Consulta: creatorFacets:"Guerrant,Richard L."
Registros recuperados: 4
Data/hora: 04/06/2024 02:18:34

Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis
Provedor de dados: 55
Autores: Façanha,Mônica C.; Gondim,Argina M.B.; Pinheiro,Valéria G.F.; Barroso,Elizabeth C.; Peloquin,Charles A.; Guerrant,Richard L.; Lima,Aldo A.M.
Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide were studied in healthy controls and patients with active pulmonary tuberculosis. A case-control study of 29 controls and 30 cases attending at the Health Center, July, 2004 to December, 2005 was conducted. The body mass index was significantly reduced in cases compared to controls (p &lt; 0.001). The intestinal paracellular transport of lactulose was significantly (p = 0.019) reduced in cases compared to controls. The transcellular transport of mannitol and the lactulose:mannitol ratio were not significantly (p = 0.0698) reduced in cases compared to controls. Low serum concentrations of rifampin, isoniazid and pyrazinamide were observed in 81% (48/59), 92% (54/59)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Bioavailability of antimycobacterial drugs; Intestinal barrier function; Rifampin; Isoniazid and pyrazinamide.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300011

Common infectious diseases and skin test anergy in children from an urban slum in Northeast Brazil
Provedor de dados: 55
Autores: Castro,Melânia X.; Soares,Alberto M.; Fonsêca,Walter; Rey,Luís C.; Guerrant,Richard L.; Lima,Aldo A. M.
BACKGROUND: Acute respiratory infection (ARI), diarrheal disease (DD) and infective dermatitis (ID) are important causes of morbidity in children under five, in Northeast Brazil. Objectives: (a) to evaluate the morbidity of ARI, DD and ID; and (b) to determine their association with cellular immunity in poor urban children from Fortaleza, Brazil. MATERIALS AND METHODS: A prospective cohort study. At enrollment, multipuncture skin-tests (Multitest CMI) were performed and interpreted according to standard procedures. Children were followed for infectious diseases by weekly home visits. RESULTS: Seventy-one children aged 6 to 21 months were recruited in an ongoing cohort of newborns. A mean of 39 (6 to 63) home visits per child were made, which detected 184.5...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diarrhea; Acute respiratory infection; Cellular immunity; Skin test; Child.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600006

AIDS-associated diarrhea and wasting in northeast Brazil is associated with subtherapeutic plasma levels of antiretroviral medications and with both bovine and human subtypes of Cryptosporidium parvum
Provedor de dados: 55
Autores: Brantley,Richard K.; Williams,K. Robert; Silva,Terezinha M.J.; Sistrom,Maria; Thielman,Nathan M.; Ward,Honorine; Lima,Aldo A. M.; Guerrant,Richard L.
Advanced HIV infection is frequently complicated by diarrhea, disruption of bowel structure and function, and malnutrition. Resulting malabsorption of or pharmacokinetic changes in antiretroviral agents might lead to subtherapeutic drug dosing and treatment failure in individual patients, and could require dose adjustment and/or dietary supplements during periods of diarrheal illness. We determined the plasma levels of antiretroviral medications in patients that had already been started on medication by their physicians in an urban infectious diseases hospital in northeast Brazil. We also obtained blood samples from patients hospitalized for diarrhea or AIDS-associated wasting, and we found reduced stavudine and didanosine levels in comparison with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Malabsorption; DdI; D4T; Pharmacokinetics.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100003

Intestinal permeability and malabsorption of rifampin and isoniazid in active pulmonary tuberculosis
Provedor de dados: 55
Autores: Pinheiro,Valéria G. F.; Ramos,Lysiane M. A.; Monteiro,Helena S. A.; Barroso,Elizabeth C.; Bushen,Oluma Y.; Façanha,Mônica C.; Peloquin,Charles A.; Guerrant,Richard L.; Lima,Aldo A. M.
Low antimycobacterial drug concentrations have been observed in tuberculosis (TB) patients under treatment. The lactulose/mannitol urinary excretion test (L/M), normally used to measure intestinal permeability, may be useful to assess drug absorption. The objective of this research was to study intestinal absorptive function and bioavailability of rifampin and isoniazid in TB patients. A cross sectional study was done with 41 patients and 28 healthy controls, using the L/M test. The bioavailabilities of rifampin (R) and isoniazid (H) were evaluated in 18 patients receiving full doses. Urinary excretion of mannitol and lactulose, measured by HPLC, was significantly lower in TB patients. The serum concentrations of the drugs were below the expected range for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pulmonary tuberculosis; Intestinal permeability; Rifampin and isoniazid intestinal malabsorption; M. tuberculosis resistance.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600003