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Anti-inflammatory and redox-protective activities of citronellal
Provedor de dados: 48
Autores: Melo,Mônica S; Guimarães,Adriana G; Santana,Michele F; Siqueira,Rosana S; De Lima,Amanda Do Carmo B; Dias,Antonio S; Santos,Márcio Roberto V; Onofre,Alexandre S.C.; Quintans,Jullyana S.S.; De Sousa,Damião P; Almeida,Jackson R.G.S.; Estevam,Charles S; Araujo,Brancilene S; Quintans-Júnior,Lucindo J.
The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p &lt; 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p &lt; 0.05) by i.p. administration of 100 and 200 mg/kg of the compound. When the redox activity was evaluated, CT (200 mg/kg) significantly reduced hepatic lipoperoxidation (p &lt; 0.001), as well as oxidation of plasmatic (p &lt; 0.05) and hepatic (p &lt; 0.01) proteins. The results of the present study support the hypothesis that CT possesses anti-inflammatory and...
Tipo: Journal article
Palavras-chave: Monoterpene; Citronellal; Anti-inflammatory; Redox.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400008