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Phylogenetic analysis, based on EPIYA repeats in the cagA gene of Indian Helicobacter pylori, and the implications of sequence variation in tyrosine phosphorylation motifs on determining the clinical outcome
Provedor de dados: Genetics and Molecular Biology
Autores: Tiwari,Santosh K.; Sharma,Vishwas; Sharma,Varun Kumar; Gopi,Manoj; Saikant,R; Nandan,Amrita; Bardia,Avinash; Gunisetty,Sivaram; Katikala,Prasanth; Habeeb,Md. Aejaz; Khan,Aleem A.; Habibullah,C.M.
The population of India harbors one of the world's most highly diverse gene pools, owing to the influx of successive waves of immigrants over regular periods in time. Several phylogenetic studies involving mitochondrial DNA and Y chromosomal variation have demonstrated Europeans to have been the first settlers in India. Nevertheless, certain controversy exists, due to the support given to the thesis that colonization was by the Austro-Asiatic group, prior to the Europeans. Thus, the aim was to investigate pre-historic colonization of India by anatomically modern humans, using conserved stretches of five amino acid (EPIYA) sequences in the cagA gene of Helicobacter pylori. Simultaneously, the existence of a pathogenic relationship of tyrosine...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Helicobacter pylori; EPIYA motifs; Tyrosine phosphorylation motifs; Haplotypes; Anatomically modern humans.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200019