Consulta: creatorFacets:"Hörner,Manfredo"
Registros recuperados: 2
Data/hora: 16/06/2024 04:31:02

Synergistic antibacterial effect of statins with the complex {[1-(4-bromophenyl)-3-phenyltriazene N 3 -oxide-κ 2 N 1 ,O 4 ](dimethylbenzylamine-κ 2 C 1 ,N 4 )palladium(II)}
Provedor de dados: 60
Autores: Rampelotto,Roberta Filipini; Lorenzoni,Vinicius Victor; Silva,Danielly da Costa; Moraes,Guilherme A. de; Serafin,Marissa Bolson; Tizotti,Maísa Kräulish; Coelho,Silvana; Zambiazi,Priscilla; Hörner,Manfredo; Hörner,Rosmari.
Abstract The treatment of infections caused by resistant microorganisms represents a big challenge in healthcare due to limited treatment options. For this reason, the discovery of new active substances which are able to perform innovative and selective actions is of great impact nowadays. Statins and triazenes (TZC) have consolidated as a promising class of compounds, characterized by the expressive biological activity, especially antimicrobial activities. The aim of this study was to assess the in vitro synergistic antibacterial effect of the association of statins and a new TZC complex {[1-(4-bromophenyl)-3-phenyltriazene N 3-oxide-κ 2 N 1,O 4](dimethylbenzylamine-κ 2 C 1,N 4)palladium(II)} (Pd(DMBA)LBr) against American Type Culture Collection (ATCC)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Statins/antimicrobial activity; Triazenide; Atorvastatin; Simvastatin.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200614

Synthesis, characterization and biological activity of a gold(I) triazenide complex against chronic myeloid leukemia cells and biofilm producing microorganisms
Provedor de dados: 60
Autores: Nunes,Melise Silveira; Garzon,Litiérri Razia; Rampelotto,Roberta Filipini; Tizotti,Maísa Kräulich; Martini,Rosiéli; Locatelli,Aline; Barbosa,Marcelo; Hörner,Manfredo; Hörner,Rosmari.
ABSTRACT The enhancement of anti-leukemia therapy and the treatment of infections caused by multidrug-resistant pathogens are major challenges in healthcare. Although a large arsenal of drugs is available, many of these become ineffective, and as a result, the discovery of new active substances occurs. Notably, triazenes (TZCs) have been consolidated as a promising class of compounds, characterized by significant biological activity, especially antiproliferative and antimicrobial properties. The aim of this study is the synthesis and characterization of a new triazenide complex of gold (I), as well as the in vitro assessment of its antiproliferative activity against the K562 cell line (Chronic Myeloid Leukemia), and antibacterial activity against bacterial...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Triazenes/synthesis/characterization/biological activity; TZC/Gold ion complexed; Chronic myeloid leukemia; Antibacterial activity.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400617