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Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
Provedor de dados: 74
Autores: Moreno,Nancy; Martínez,José A.; Blanco,Zorella; Osorio,Leidys; Hackshaw,Patrick.
Seven polymorphic sites in the beta-globin gene cluster were analyzed on a sample of 96 chromosomes of Venezuelan sickle cell patients from the State of Aragua. The Benin haplotype was predominant with a frequency of 0.479, followed by the Bantu haplotype (0.406); a minority of cases with other haplotypes was also identified: atypical Bantu A2 (0.042), Senegal (0.031), atypical Bantu A7 (0.021) and Saudi Arabia/Indian (0.021) haplotypes; however, the Cameroon haplotype was not identified in this study. Our results are in agreement with the historical records that establish Sudanese and Bantu origins for the African slaves brought into Venezuela.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Haplotypes; Beta-globin gene cluster; Sickle cell.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100005