Consulta: creatorFacets:"Hei,Ming-Yan"
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Data/hora: 17/06/2024 14:22:57

Decreased levels of pNR1 S897 protein in the cortex of neonatal Sprague Dawley rats with hypoxic-ischemic or NMDA-induced brain damage
Provedor de dados: 56
Autores: Hei,Ming-Yan; Tao,Hui-Kang; Tang,Qin; Yu,Bo; Zhao,Ling-Ling.
Our objective was to investigate the protein level of phosphorylated N-methyl-D-aspartate (NMDA) receptor-1 at serine 897 (pNR1 S897) in both NMDA-induced brain damage and hypoxic-ischemic brain damage (HIBD), and to obtain further evidence that HIBD in the cortex is related to NMDA toxicity due to a change of the pNR1 S897 protein level. At postnatal day 7, male and female Sprague Dawley rats (13.12 ± 0.34 g) were randomly divided into normal control, phosphate-buffered saline (PBS) cerebral microinjection, HIBD, and NMDA cerebral microinjection groups. Immunofluorescence and Western blot (N = 10 rats per group) were used to examine the protein level of pNR1 S897. Immunofluorescence showed that control and PBS groups exhibited significant neuronal...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: N-methyl-D-aspartate receptor 1; Phosphorylation; Neonate; Hypoxic-ischemic brain damage; Cerebral microinjection; Brain damage.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001000012