Consulta: creatorFacets:"Iacobas,D.A."
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Cardiac gene expression and systemic cytokine profile are complementary in a murine model of post-ischemic heart failure
Provedor de dados: 56
Autores: Lachtermacher,S.; Esporcatte,B.L.B.; Montalvão,F.; Costa,P.C.; Rodrigues,D.C.; Belem,L.; Rabischoffisky,A.; Faria Neto,H.C.C.; Vasconcellos,R.; Iacobas,S.; Iacobas,D.A.; Dohmann,H.F.R.; Spray,D.C.; Goldenberg,R.C.S.; Campos-de-Carvalho,A.C.
After myocardial infarction (MI), activation of the immune system and inflammatory mechanisms, among others, can lead to ventricular remodeling and heart failure (HF). The interaction between these systemic alterations and corresponding changes in the heart has not been extensively examined in the setting of chronic ischemia. The main purpose of this study was to investigate alterations in cardiac gene and systemic cytokine profile in mice with post-ischemic HF. Plasma was tested for IgM and IgG anti-heart reactive repertoire and inflammatory cytokines. Heart samples were assayed for gene expression by analyzing hybridization to AECOM 32k mouse microarrays. Ischemic HF significantly increased the levels of total serum IgM (by 5.2-fold) and total IgG (by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Experimental post-ischemic heart failure; Anti-heart antibodies; Cytokines; Immunoarray; RNAm - Microarray.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400009