Consulta: creatorFacets:"Isbil-Buyukcoskun,N."
Registros recuperados: 2
Data/hora: 02/06/2024 09:25:42

Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Cam-Etoz,B.; Isbil-Buyukcoskun,N.; Ozluk,K.
Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V1 receptors or the central cholinergic system play roles in these cardiovascular effects. Blood pressure and HR were observed before and for 30 min following drug injections. The following results were obtained: 1) icv ADM (750 ng/10 µL) caused an increase in both blood pressure and HR (DMAP = 11.8 ± 2.3 mmHg and ΔHR = 39.7 ± 4.8 bpm). 2) Pretreatment with a CGRP receptor antagonist (CGRP8-37) and ADM receptor antagonist (ADM22-52)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adrenomedullin; Blood pressure; Vasopressin; Atropine; Mecamylamine.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300011

Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Isbil-Buyukcoskun,N.; Gulec,G.; Ozluk,K.; Ulus,I.H.
In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv) choline (50, 100 and 150 µg) on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin system blockade on blood pressure increase induced by choline (150 µg, icv), an angiotensin-converting enzyme inhibitor, captopril (25 and 50 µg, icv), was administered 3 min before choline. Twenty-five µg captopril did not block the pressor effect of choline, while 50 µg captopril blocked it significantly....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Choline; Captopril; Intracerebroventricular choline; Blood pressure.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600018