Consulta: creatorFacets:"Izquierdo,I."
Registros recuperados: 6
Data/hora: 04/06/2024 04:32:33

Involvement of hippocampal AMPA glutamate receptor changes and the cAMP/protein kinase A/CREB-P signalling pathway in memory consolidation of an avoidance task in rats
Provedor de dados: 56
Autores: Bernabeu,R.; Cammarota,M.; Izquierdo,I.; Medina,J.H.
Training in step-down inhibitory avoidance (0.3-mA footshock) is followed by biochemical changes in rat hippocampus that strongly suggest an involvement of quantitative changes in glutamate AMPA receptors, followed by changes in the dopamine D1 receptor/cAMP/protein kinase A (PKA)/CREB-P signalling pathway in memory consolidation. AMPA binding to its receptor and levels of the AMPA receptor-specific subunit GluR1 increase in the hippocampus within the first 3 h after training (20-70%). Binding of the specific D1 receptor ligand, SCH23390, and cAMP levels increase within 3 or 6 h after training (30-100%). PKA activity and CREB-P levels show two peaks: a 35-40% increase 0 h after training, and a second increase 3-6 h later (35-60%). The results correlate...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Glutamate AMPA receptors; CAMP/PKA/CREB pathway; Memory formation; Rat hippocampus.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800008

The brain decade in debate: I. Neurobiology of learning and memory
Provedor de dados: 56
Autores: Baddeley,A.; Bueno,O; Cahill,L.; Fuster,J.M.; Izquierdo,I.; McGaugh,J.L.; Morris,R.G.M.; Nadel,L.; Routtenberg,A.; Xavier,G.; Da Cunha,C.
This article is a transcription of an electronic symposium in which some active researchers were invited by the Brazilian Society for Neuroscience and Behavior (SBNeC) to discuss the last decade's advances in neurobiology of learning and memory. The way different parts of the brain are recruited during the storage of different kinds of memory (e.g., short-term vs long-term memory, declarative vs procedural memory) and even the property of these divisions were discussed. It was pointed out that the brain does not really store memories, but stores traces of information that are later used to create memories, not always expressing a completely veridical picture of the past experienced reality. To perform this process different parts of the brain act as...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Memory; Learning; Hippocampus; Prefrontal; Cortex; Amygdala; Memory systems.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900002

Agents that affect cAMP levels or protein kinase A activity modulate memory consolidation when injected into rat hippocampus but not amygdala
Provedor de dados: 56
Autores: Bevilaqua,L.; Ardenghi,P.; Schröder,N.; Bromberg,E.; Quevedo,J.; Schmitz,P.K.; Bianchin,M.; Walz,R.; Schaeffer,E.; Medina,J.H.; Izquierdo,I.
Male Wistar rats were trained in one-trial step-down inhibitory avoidance using a 0.4-mA footshock. At various times after training (0, 1.5, 3, 6 and 9 h for the animals implanted into the CA1 region of the hippocampus; 0 and 3 h for those implanted into the amygdala), these animals received microinfusions of SKF38393 (7.5 µg/side), SCH23390 (0.5 µg/side), norepinephrine (0.3 µg/side), timolol (0.3 µg/side), 8-OH-DPAT (2.5 µg/side), NAN-190 (2.5 µg/side), forskolin (0.5 µg/side), KT5720 (0.5 µg/side) or 8-Br-cAMP (1.25 µg/side). Rats were tested for retention 24 h after training. When given into the hippocampus 0 h post-training, norepinephrine enhanced memory whereas KT5720 was amnestic. When given 1.5 h after training, all treatments were ineffective....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Memory formation; Memory modulation; Hippocampus; Amygdala; CAMP/PKA/CREB-P pathway; Dopamine D; Receptors; SS-adrenoceptors; 5HT1A receptors.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800009

Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning
Provedor de dados: 56
Autores: Vianna,M.R.M.; Izquierdo,L.A.; Barros,D.M.; de Souza,M.M.; Rodrigues,C.; Sant'Anna,M.K.; Medina,J.H.; Izquierdo,I.
Rats implanted bilaterally with cannulae in the CA1 region of the dorsal hippocampus or the entorhinal cortex were submitted to either a one-trial inhibitory avoidance task, or to 5 min of habituation to an open field. Immediately after training, they received intrahippocampal or intraentorhinal 0.5-µl infusions of saline, of a vehicle (2% dimethylsulfoxide in saline), of the glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphono pentanoic acid (AP5), of the protein kinase A inhibitor Rp-cAMPs (0.5 µg/side), of the calcium-calmodulin protein kinase II inhibitor KN-62, of the dopaminergic D1 antagonist SCH23390, or of the mitogen-activated protein kinase kinase inhibitor PD098059. Animals were tested in each task 24 h after...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Habituation learning; One-trial avoidance; Memory consolidation; Pharmacology of memory consolidation; Hippocampus; Entorhinal cortex.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200011

Effect of inhibitory avoidance training on [3H]-glutamate binding in the hippocampus and parietal cortex of rats
Provedor de dados: 56
Autores: Schröder,N.; de-Paris,F.; Roesler,R.; Medina,J.H.; Souza,D.O.; Izquierdo,I.
Glutamate receptors have been implicated in memory formation. The aim of the present study was to determine the effect of inhibitory avoidance training on specific [3H]-glutamate binding to membranes obtained from the hippocampus or parietal cortex of rats. Adult male Wistar rats were trained (0.5-mA footshock) in a step-down inhibitory avoidance task and were sacrificed 0, 5, 15 or 60 min after training. Hippocampus and parietal cortex were dissected and membranes were prepared and incubated with 350 nM [3H]-glutamate (N = 4-6 per group). Inhibitory avoidance training induced a 29% increase in glutamate binding in hippocampal membranes obtained from rats sacrificed at 5 min (P&amp;lt;0.01), but not at 0, 15, or 60 min after training, and did not affect...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Glutamate receptor hippocampus parietal cortex long-term potentiation emotional learning; Memory.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200011

Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation
Provedor de dados: 56
Autores: Walz,R.; Roesler,R.; Reinke,A.; Martins,M.R.; Quevedo,J.; Izquierdo,I.
We studied the effects of infusion of nerve growth factor (NGF) into the hippocampus and entorhinal cortex of male Wistar rats (250-300 g, N = 11-13 per group) on inhibitory avoidance retention. In order to evaluate the modulation of entorhinal and hippocampal NGF in short- and long-term memory, animals were implanted with cannulae in the CA1 area of the dorsal hippocampus or entorhinal cortex and trained in one-trial step-down inhibitory avoidance (foot shock, 0.4 mA). Retention tests were carried out 1.5 h or 24 h after training to measure short- and long-term memory, respectively. Immediately after training, rats received 5 µl NGF (0.05, 0.5 or 5.0 ng) or saline per side into the CA1 area and entorhinal cortex. The correct position of the cannulae was...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Nerve growth factor; Hippocampus; Entorhinal cortex; Short- and long-term memory; Inhibitory avoidance; Rat.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100009