Consulta: creatorFacets:"Jalali,A"
Registros recuperados: 3
Data/hora: 09/06/2024 04:17:44

In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Jalali,A; Pipelzadeh,M H; Seyedian,R; Rahmani,A H; Omidian,N.
The available Razi Institute antivenom is still, empirically, used by intramuscular (IM) administration for the treatment of scorpion stings in humans by six medically dangerous species including Hemiscorpius lepturus (H. lepturus). The aim of this study was to assess the neutralizing ability and effectiveness of the antivenom in inhibiting hemoglobinuria, biochemical changes, increased microalbuminuria and urinary lactate dehydrogenase (LDH) following H. lepturus sting. Simultaneous intramuscular administration of 10 μL and 100 μL of antivenom, after 24 hours, had no significant preventive effect on the extent and degree of hemoglobinuria or proteinuria produced in venom-treated rats. After IM administration of antivenom, no significant changes in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hemiscorpius lepturus; Scorpion; Venom; Hemolysis; Antivenom.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000200004

A biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Seyedian,R; Jalali,A; Babaee,MH; Pipelzadeh,MH; Rezaee,S.
The purpose of the present study was to investigate the biodistribution profile of the venom of Hemiscorpius lepturus, the most dangerous scorpion in Iran. Blood and tissue samples were taken at various predetermined intervals during a 400-minute period for the venom and a 360-minute period for the antivenom in rats. The radio-iodination was carried out using the chloramine-T method. The results showed that the descending order of venom uptake was skin, kidneys and intestine, respectively. The descending order of polyclonal antivenom uptake was kidneys, intestine, heart and lungs. The calculated pharmacokinetic parameters of the venom were Telimination half-life = 521.5 ± 12.6 minutes; Vd/F (apparent volume of distribution) = 14.9 ± 3.3 mL; clearance...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hemiscorpius lepturus scorpion venom; Polyvalent antivenom; Pharmacokinetic parameters; Tissue distribution.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000400005

Symptom patterns in adult patients stung by scorpions with emphasis on coagulopathy and hemoglubinuria
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Rahmani,AH; Jalali,A.
The aim of this retrospective descriptive study was to highlight clinical manifestations 24-48 hours following referral of adult patients stung by scorpions. This study contains clinical records of 290 patients admitted to Razi Hospital due to scorpion stings in Ahvaz, Khuzestan province from 2004 to 2005. The most prevalent patient age range was 15-20 years (30.3%). The most common sting location (41.3%) was the upper extremity; nearly half (49.6%) had been admitted within 6-24 hours following sting, while a large majority (85.5%) were hospitalized for 24-48 hours. A total of 116 (40%) patients presented hemoglobinuria. Contrary to available prior reports, the symptoms in none of the patients were accompanied by neurological manifestations. Kidney...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Scorpion; Stings; Signs and symptoms; Coagulopathy; Hemoglobinuria.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000400011