Consulta: creatorFacets:"Joubert,Anna Margaretha"
Registros recuperados: 1
Data/hora: 10/06/2024 08:04:22

In vitro assessment of a computer-designed potential anticancer agent in cervical cancer cells
Provedor de dados: 48
Autores: Visagie,Michelle Helen; Jaiswal,Seema Rummurat; Joubert,Anna Margaretha.
BACKGROUND: Computer-based technology is becoming increasingly essential in biological research where drug discovery programs start with the identification of suitable drug targets. 2-Methoxyestradiol (2ME2) is a 17ß-estradiol metabolite that induces apoptosis in various cancer cell lines including cervical cancer, breast cancer and multiple myeloma. Owing to 2ME2's poor in vivo bioavailability, our laboratory in silico-designed and subsequently synthesized a novel 2ME2 analogue, 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol), using receptor- and ligand molecular modeling. In this study, the biological effects of ESE-15-ol (180 nM) and its parent molecule, 2ME2 (1 &amp;#956;M), were assessed on morphology and apoptosis induction in...
Tipo: Journal article
Palavras-chave: Morphology; Apoptosis; Cervical cancer; ESE-15-ol.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100043